[1]王福财,周智涵,马丽浩.铁死亡在鼻咽癌发生发展及治疗中的研究进展[J].华侨大学学报(自然科学版),2025,46(4):361-368.[doi:10.11830/ISSN.1000-5013.202503027]
　WANG Fucai,ZHOU Zhihan,MA Lihao.Research Progress of Ferroptosis in Pathogenesis and Therapy of Nasopharyngeal Carcinoma[J].Journal of Huaqiao University(Natural Science),2025,46(4):361-368.[doi:10.11830/ISSN.1000-5013.202503027]
点击复制

铁死亡在鼻咽癌发生发展及治疗中的研究进展()
分享到：

《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第46卷
期数:
2025年第4期
页码:
361-368
栏目:
出版日期:
2025-07-16

文章信息/Info

Title:
Research Progress of Ferroptosis in Pathogenesis and Therapy of Nasopharyngeal Carcinoma
文章编号:
1000-5013(2025)04-0361-08
作者:
王福财;  周智涵;  马丽浩
华侨大学 医学院, 福建 泉州 362021
Author(s):
WANG Fucai;  ZHOU Zhihan;  MA Lihao
School of Medicine, Huaqiao University, Quanzhou 362021, China
关键词:
鼻咽癌;  铁死亡;  发生机制;  耐药性
Keywords:
nasopharyngeal carcinoma;  ferroptosis;  mechanism;  antibiotics resistance
分类号:
R739.6
DOI:
10.11830/ISSN.1000-5013.202503027
文献标志码:
A
摘要:
通过查阅近年的相关文献,综述铁死亡的概念、特征及其在鼻咽癌治疗中的研究进展。结果表明:铁死亡的发生机制复杂且在鼻咽癌治疗中发挥着关键作用;鼻咽癌患者的长期生存率虽然明显增加,但远处转移和放化疗耐药性仍然是鼻咽癌患者的治疗难点;铁死亡作为一种以活性氧和脂质过氧化物水平升高为特征的新型细胞死亡方式,有望成为鼻咽癌临床干预的一个新靶点。
Abstract:
By reviewing the relevant literature in recent years, the concept, characteristics and research progress of ferroptosis in the treatment of nasopharyngeal carcinoma were reviewed. The results showed that the mechanism of ferroptosis was complex and it played a key role in the treatment of nasopharyngeal carcinoma. Although the long-term survival rate of nasopharyngeal carcinoma patients had significantly increased, distant metastasis and resistance to radiotherapy and chemotherapy remained the treatment difficulties for nasopharyngeal carcinoma patients. As a novel mode of cell death characterized by elevated levels of reactive oxygen species and lipid peroxides, ferroptosis was expected to become a new target for clinical intervention in nasopharyngeal carcinoma.

参考文献/References:

[1] LEI Guang,ZHANG Yilei,HONG Ting,et al.Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity[J].Oncogene,2021,40(20):3533-3547.DOI:10.1038/s41388-021-01790-w.
[2] XU Ying,WANG Qian,LI Xiaozhen,et al.Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis[J].Environmental Toxicology,2021,36(2):257-266.DOI:10.1002/tox.23031.
[3] ZHANG Wenlu,WEN Wen,TAN Ran,et al.Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia(Review)[J].Oncology Letters,2024,28(6):574.DOI:10.3892/ol.2024.14707.
[4] ZHANG Yuna,CAO Yujie,LUO Lin,et al.The global, regional, and national burden of nasopharyngeal carcinoma and its attributable risk factors in 204 countries and territories, 1990-2019[J].Acta Oto-Laryngologica,2022,142(7/8):590-609.DOI:10.1080/00016489.2022.2111711.
[5] DIXON S J,LEMBERG K M,LAMPRECHT M R,et al.Ferroptosis: An iron-dependent form of nonapoptotic cell death[J].Cell,2012,149(5):1060-1072.DOI:10.1016/j.cell.2012.03.042.
[6] SHI Chunlei,XIE Yongjie,LI Xueyang,et al.Identification of ferroptosis-related genes signature predicting the efficiency of invasion and metastasis ability in colon adenocarcinoma[J].Frontiers in Cell and Developmental Biology,2021,9:815104.DOI:10.3389/fcell.2021.815104.
[7] 张展瑞,刘红雨,陈军.线粒体在铁死亡中的作用及其与肿瘤的关系[J].中国肺癌杂志,2024,27(10):785-791.DOI:10.3779/j.issn.1009-3419.2024.102.34.
[8] 王新峰,姚宇欣,王攀.铁死亡相关机制及其在恶性肿瘤中的研究进展[J].中国医学科学院学报,2023,45(4):647-654.DOI:10.3881/j.issn.1000-503X.15379.
[9] LI Fengjiao,LONG Huizhi,ZHOU Ziwei,et al.System X-c/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy[J].Frontiers in Pharmacology,2022,13:910292.DOI:10.3389/fphar.2022.910292.
[10] LIANG K A,CHIH H Y,LIU I J,et al.Tumor-targeted delivery of hyaluronic acid/polydopamine-coated Fe2+-doped nano-scaled metal-organic frameworks with doxorubicin payload for glutathione depletion-amplified chemodynamic-chemo cancer therapy[J].Journal of Colloid and Interface Science,2025,677:400-415.DOI:10.1016/j.jcis.2024.07.241.
[11] PUNZIANO C,TROMBETTI S,CESARO E,et al.Antioxidant systems as modulators of ferroptosis: Focus on transcription factors[J].Antioxidants(Basel),2024,13(3):298.DOI:10.3390/antiox13030298.
[12] POPE L E,DIXON S J.Regulation of ferroptosis by lipid metabolism[J].Trends in Cell Biology,2023,33(12):1077-1087.DOI:10.1016/j.tcb.2023.05.003.
[13] LIANG Deguang,MINIKES A M,JIANG Xuejun.Ferroptosis at the intersection of lipid metabolism and cellular signaling[J].Molecular Cell,2022,82(12):2215-2227.DOI:10.1016/j.molcel.2022.03.022.
[14] KOPPULA P,ZHUANG Li,GAN Boyi.Cystine transporter SLC7A11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy[J].Protein & Cell,2021,12(8):599-620.DOI:10.1007/s13238-020-00789-5.
[15] WANG Kun,SHI Xu,LIN Hongjin,et al.Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus[J].Journal of Environmental Sciences(China),2025,148:13-26.DOI:10.1016/j.jes.2024.01.002.
[16] GUO Jun,CHEN Long,MA Min.Ginsenoside Rg1 suppresses ferroptosis of renal tubular epithelial cells in sepsis-induced acute kidney injury via the FSP1-CoQ(10)-NAD(P)H pathway[J].Current Medicinal Chemistry,2024,31(15):2119-2132.DOI:10.2174/0929867330666230607125054.
[17] NISHIZAWA H,YAMANAKA M,IGARASHI K.Ferroptosis: Regulation by competition between NRF2 and BACH1 and propagation of the death signal[J].FEBS Journal,2023,290(7):1688-1704.DOI:10.1111/febs.16382.
[18] NIU Xiaolong,SUN Wei,TANG Xiaohang,et al.Bufalin alleviates inflammatory response and oxidative stress in experimental severe acute pancreatitis through activating Keap1-Nrf2/HO-1 and inhibiting NF-κB pathways[J].International Immunopharmacology,2024,142:113113.DOI:10.1016/j.intimp.2024.113113.
[19] TANG Linglong,CHEN Yupei,CHEN Chuanben,et al.The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma[J].Cancer Communications(Lond),2021,41(11):1195-1227.DOI:10.1002/cac2.12218.
[20] 陶倩,刘念,陈静,等.铁死亡与肿瘤免疫[J].中南大学学报(医学版),2024,49(8):1309-1315.DOI:10.11817/j.issn.1672-7347.2024.240389.
[21] UBELLACKER J M,TASDOGAN A,RAMESH V,et al.Lymph protects metastasizing melanoma cells from ferroptosis[J].Nature,2020,585(7823):113-118.DOI:10.1038/s41586-020-2623-z.
[22] ZUO Yingbing,ZHANG Yinfeng,ZHANG Rui,et al.Ferroptosis in cancer progression: Role of noncoding RNAs[J].International Journal of Biological Sciences,2022,18(5):1829-1843.DOI:10.7150/ijbs.66917.
[23] LI Lijie,ZENG Jie,HE Sili,et al.METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer[J].Cancer Biology & Therapy,2024,25(1):2349429.DOI:10.1080/15384047.2024.2349429.
[24] HUANG Weimei,LI Zhixun,WU Yinghui,et al.m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis[J].Translational Oncology,2023,27:101576.DOI:10.1016/j.tranon.2022.101576.
[25] YUAN Li,LI Shibing,CHEN Qiuyuan,et al.EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma[J].Cell Death and Differentiation,2022,29(8):1513-1527.DOI:10.1038/s41418-022-00939-8.
[26] QIU Lin,ZHOU Rui,ZHOU Ling,et al.CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR[J].Frontiers in Oncology,2022,12:931749.DOI:10.3389/fonc.2022.931749.
[27] CHEN Wenhui,BAO Lili,REN Qianqian,et al.SCARB1 in extracellular vesicles promotes NPC metastasis by co-regulating M1 and M2 macrophage function[J].Cell Death Discovery,2023,9(1):323.DOI:10.1038/s41420-023-01621-9.
[28] 焦泉慧.LARP1通过调控铁死亡介导鼻咽癌细胞中顺铂的化疗敏感性[D].南昌:江西中医药大学,2023.
[29] ZHONG Xing,ZHANG Weiwei,ZHANG Weiming,et al.FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-κB/STAT3/GPX4 axis[J].Cancer Biology & Therapy,2024,25(1):2403197.DOI:10.1080/15384047.2024.2403197.
[30] DIKE P E,HWANG B J,CAMPBELL T,et al.HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells[J].Biochemical and Biophysical Research Communications,2024,736:150859.DOI:10.1016/j.bbrc.2024.150859.
[31] WANG Weimin,GREEN M,CHOI J E,et al.CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy[J].Nature,2019,569(7755):270-274.DOI:10.1038/s41586-019-1170-y.
[32] CHEN Wenhui,ZUO Fan,ZHANG Kaiwen,et al.Exosomal MIF derived from nasopharyngeal carcinoma promotes metastasis by repressing ferroptosis of macrophages[J].Frontiers in Cell and Developmental Biology,2021,9:791187.DOI:10.3389/fcell.2021.791187.
[33] LI Fei,XU Ting,CHEN Peiling,et al.Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3[J].International Journal of Biological Sciences,2022,18(15):5858-5872.DOI:10.7150/ijbs.76162.
[34] PU Xiaoping,WU Hong,LIU Xiaoyan,et al.PRMT4 reduced erastin-induced ferroptosis in nasopharyngeal carcinoma cisplatin-resistant cells by Nrf2/GPX4 pathway[J].Journal of Environmental Pathology,Toxicology and Oncology,2025,44(1):57-71.DOI:10.1615/JEnvironPatholToxicolOncol.2024053754.
[35] XIAO Juan,LUO Chenggen,LI Anmao,et al.Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling[J].International Immunopharmacology,2024,133:112010.DOI:10.1016/j.intimp.2024.112010.
[36] WU Yao,JIA Qunying,TANG Qi,et al.Berberine-mediated ferroptosis through system X-c/GSH/GPX4 axis inhibits metastasis of nasopharyngeal carcinoma[J].Journal of Cancer,2024,15(3):685-698.DOI:10.7150/jca.90574.
[37] BAKAR-ATES F,OZKAN E.Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation[J].Toxicology in Vitro,2024,94:105732.DOI:10.1016/j.tiv.2023.105732.
[38] WANG Dan,TANG Le,CHEN Mingjian,et al.Nanocarriers targeting circular RNA ADARB1 boost radiosensitivity of nasopharyngeal carcinoma through synergically promoting ferroptosis[J].ACS Nano,2024,18(45):31055-31075.DOI:10.1021/acsnano.4c07676.
[39] WU Zhiyi,QU Qingsong.Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells[J].Journal of Toxicological Sciences,2024,49(9):399-408.DOI:10.2131/jts.49.399.
[40] LIU Feng,TANG Ling,LIU Huai,et al.Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2[J].Cell Death & Disease,2024,15(4):279.DOI:10.1038/s41419-024-06671-0.
[41] ZHANG Xinyu,CHEN Yanhong,WANG Shuhui,et al.TianTan vaccinia virus-based EBV vaccines targeting both latent and lytic antigens elicits potent immunity against lethal EBV challenge in humanized mice[J].Emerging Microbes & Infections,2024,13(1):2412640.DOI:10.1080/22221751.2024.2412640.
[42] 胡桐,勾文峰,任中昊,等.淫羊藿素通过调控铁死亡增加鼻咽癌细胞的放射敏感性[J].南方医科大学学报,2023,43(10):1665-1673.DOI:10.12122/j.issn.1673-4254.2023.10.03.
[43] CHEN Yuting,FENG Yuanyuan,LIN Yanling,et al.GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4[J].British Journal of Cancer,2024,130(5):755-768.DOI:10.1038/s41416-024-02574-1.
[44] CUI Kaisa,WANG Kang,HUANG Zhaohui.Ferroptosis and the tumor microenvironment[J].Journal of Experimental and Clinical Cancer Research,2024,43(1):315.DOI:10.1186/s13046-024-03235-0.
[45] ZHOU Ji,GUO Tianyao,ZHOU Lin,et al.The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma[J].Scientific Reports,2023,13(1):1861.DOI:10.1038/s41598-023-28897-2.

相似文献/References:

[1]朱亚玲,方杉杉,黎祎杰,等.肝细胞癌铁死亡特征基因的ceRNA调控网络构建及分析[J].华侨大学学报(自然科学版),2024,45(6):746.[doi:10.11830/ISSN.1000-5013.202401010]
　ZHU Yaling,FANG Shanshan,LI Yijie,et al.Construction and Analysis of ceRNA Regulatory Network of Ferroptosis Feature Genes in Hepatocellular Carcinoma[J].Journal of Huaqiao University(Natural Science),2024,45(4):746.[doi:10.11830/ISSN.1000-5013.202401010]

备注/Memo

备注/Memo:
收稿日期: 2025-03-12
通信作者: 王福财(1978-),男,副教授,博士,主要从事肿瘤的免疫发病机制的研究。E-mail:wfc@hqu.edu.cn。
基金项目: 国家自然科学基金资助项目(81860354); 福建省泉州市高层次人才创新创业项目(2022C015R)
更新日期/Last Update: 2025-07-20