[1]王国权,庞素秋,林俊生,等.石墨烯及其衍生物在生物医药领域的研究进展[J].华侨大学学报(自然科学版),2018,39(6):787-793.[doi:10.11830/ISSN.1000-5013.201705036]
　WANG Guoquan,PANG Suqiu,LIN Junsheng,et al.Research Progress of Graphene and Its Derivatives Biomedicine Field[J].Journal of Huaqiao University(Natural Science),2018,39(6):787-793.[doi:10.11830/ISSN.1000-5013.201705036]
点击复制

石墨烯及其衍生物在生物医药领域的研究进展()
分享到：

《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第39卷
期数:
2018年第6期
页码:
787-793
栏目:
出版日期:
2018-11-20

文章信息/Info

Title:
Research Progress of Graphene and Its Derivatives Biomedicine Field
文章编号:
1000-5013(2018)06-0787-07
作者:
王国权1; 2;  庞素秋3;  林俊生1; 2;  刁勇1; 2
1. 华侨大学 生物医学学院, 福建 泉州 362021;2. 华侨大学 医学院, 福建 泉州 362021;3. 中国人民解放军第180医院 临床药学科, 福建 泉州 362000
Author(s):
WANG Guoquan1; 2;  PANG Suqiu3;  LIN Junsheng1; 2;  DIAO Yong1; 2
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. School of Medicine, Huaqiao University, Quanzhou 362021, China; 3. Department of Clinical Pharmacy, The 180th Hospital People’s Liberation Army, Quanzhou 362000, China
关键词:
石墨烯;  纳米材料;  功能化;  生物医药
Keywords:
graphene;  nanomaterials;  functional;  biomedicine
分类号:
R319
DOI:
10.11830/ISSN.1000-5013.201705036
文献标志码:
A
摘要:
综述了石墨烯及其衍生物氧化石墨烯和功能化石墨烯的结构特性、生物学特性,以及其在生物传感器、药物载体、光线疗法、生物成像和组织工程材料等生物医药方面的研究进展.结果表明:石墨烯及其衍生物特殊的结构、优异的性能为疾病诊断及临床用药提供新的可能,在生物医药方面具有很大的应用前景.
Abstract:
In this paper, we reviewed graphene and its derivatives, oxide-graphene and functionalized-graphene, including their structures, biological characteristics, and applications in biomedicine fields such as biosensors, drug carrier, light therapy, biological imaging, tissue engineering materials, and so on. The results shows that graphene and its derivatives have special structure and outstanding performance to provide new possibilities for disease diagnosis and clinical medicine, even have great application prospects in biomedicine.

参考文献/References:

[1] GAO Yuan,ZOU Xin,ZHAO Xiaojun,et al.Graphene oxide-based magnetic fluorescent hybrids for drug delivery and cellular imaging[J].Colloids Surf B Biointerfaces,2013,112:128-133.DOI:10.1016/j.colsurfb.2013.07.020.
[2] XU Cheng,YANG Darong,MEI Lin,et al.Targeting chemophotothermal therapy of hepatoma by gold nanorods/graphene oxide core/shell nanocomposites[J].ACS Appl Mater Interfaces,2013,5(24):12911-12920.DOI:10.1021/am404714w.
[3] KIM J,COTE L J,KIM F,et al.Graphene oxide sheets at interfaces[J].J Am Chem Soc,2010,132(23):8180-8186.DOI:10.1021/ja102777p.
[4] GUO Fei,KIM F,HAN T H,et al.Hydration-responsive folding and unfolding in graphene oxide liquid crystal phases[J].ACS Nano,2011,5(10):8019-8025.DOI:10.1021/nn2025644.
[5] KIM F,COTE L J,HUANG Jiaxing.Graphene oxide: Surface activity and two-dimensional assembly[J].Adv Mater,2010,22(17):1954-1958.DOI:10.1002/adma.200903932.
[6] YANG Xiaoying,ZHANG Xiaoyan,LIU Zunfeng,et al.High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide[J].J Phys Chem C,2008,112(45):17554-17558.DOI:10.1021/jp806751k.
[7] ZHANG Xiaoyong,YIN Jilei,PENG Cheng,et al.Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration[J].Carbon,2011,49(3):986-995.DOI:10.1016/j.carbon.2010.11.005.
[8] 赵媛媛,殷婷婕,霍美蓉,等.石墨烯及其衍生物氧化石墨烯作为新型药物载体材料在肿瘤治疗领域的应用研究[J].药学进展,2015,39(1):32-39.
[9] TAN Jingting,MENG Na,FAN Yunting,et al.Hydroxypropyl-β-cyclodextrin-graphene oxide conjugates: Carriers for anti-cancer drugs[J].Mater Sci Eng C,2016,61:681-687.DOI:10.1016/j.msec.2015.12.098.
[10] 刘艳,牛卫芬.基于石墨烯壳聚糖辣根过氧化物酶的H2O2生物传感器的研制[J].分析试验室,2012,31(8):79-82.DOI:10.13595/j.cnki.issn1000-0720.2012.0236.
[11] 王丹丹,曾延波,刘海清,等.石墨烯修饰电极分子印迹电化学传感器的研制及其对多巴胺的测定[J].分析测试学报,2013,32(5):581-585.
[12] ZHANG Yan,LIU Yue,ZHEN Shujun,et al.Graphene oxide as an efficient signal-to-background enhancer for DNA detection with a long range resonance energy transfer strategy[J].Chem Commun,2011,47(42):11718-11720.DOI:10.1039/C1CC14491J.
[13] LIU Fei,CHOI J Y,SEO T S.Graphene oxide arrays for detecting specific DNA hybridization by fluorescence resonance energy transfer[J].Biosens Bioelectron,2010,25(10):2361-2365.DOI:10.1016/j.bios.2010.02.022.
[14] LI Ming,LIU Qian,JIA Zhaojun,et al.Electrophoretic deposition and electrochemical behavior of novel graphene oxide-hyaluronic acid-hydroxyapatite nanocomposite coatings[J].Appl Surf Sci,2013,284(11):804-810.DOI:10.1016/j.apsusc.2013.08.012.
[15] ZHOU Ting,ZHOU Xiaoming,XING Da.Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier[J].Biomaterials,2014,35(13):4185-4194.DOI:10.1016/j.biomaterials.2014.01.044.
[16] BAO Hongqian,PAN Yongzheng,PING Yuan,et al.Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery[J].Small,2011,7(11):1569-1578.DOI:10.1002/smll.201100191.
[17] YANG Xiaoying,ZHANG Xiaoyan,LIU Zunfeng,et al.High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide[J].J Phys Chem C,2008,112(45):17554-17558.DOI:10.1021/jp806751k.
[18] YANG Xiaoying,WANG Yinsong,HUANG Xin,et al.Multifunctionalized graphene oxide based anticancer drug carrier with dual-targeting function and pH-sensitivity[J].J Mater Chem,2010,21(10):3448-3454.DOI:10.1039/C0JM02494E.
[19] ZHANG Liming,XIA Jingguang,ZHAO Qinghuan,et al.Functional graphene oxide as nanocarriers for controlled loading and targeted delivery of mixed anticancer drugs[J].Small,2010,6(4):537-544.DOI:10.1002/smll.200901680.
[20] MA Dong,LIN Jiantao,CHEN Yuyun,et al.In situ gelation and sustained release of an antitumor drug by graphene oxide nanosheets[J].Carbon,2012,50(8):3001-3007.DOI:10.1016/j.carbon.2012.02.083.
[21] CHEN Hui,WANG Zhuyuan,ZONG Shenfei,et al.SERS-fluorescence monitored drug release of a redox-responsive nanocarrier based on graphene oxide in tumor cells[J].ACS Appl Mater Interfaces,2014,6(20):17526-17533.DOI:10.1021/am505160v.
[22] YANG Xiaoying,NIU Gaoli,CAO Xiufen,et al.The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA [J].J Mater Chem,2012,22(14):6649-6654.DOI:10.1039/C2JM14718A.
[23] ZHANG Liming,LU Zhuoxuan,ZHAO Qinghuan,et al.Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide [J].Small,2011,7(4):460-464.DOI:10.1002/smll.201001522.
[24] 曹秀芬,冯福立,杨晓英,等.功能化氧化石墨烯作为基因和抗肿瘤药物纳米载体的制备及性能研究 [J].天津医科大学学报,2013,19(3):178-181.
[25] SHANMUGAM V,SELVAKUMAR S,YEH C S.Near-infrared light-responsive nanomaterials in cancer therapeutics[J].Chem Soc Rev,2014,43(17):6254-6287.DOI:10.1039/C4CS00011K.
[26] ZHOU Lin,ZHOU Lin,WEI Shaohua,et al.Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system[J].J Photochem Photobiol B,2014,135(3):7-16.DOI:10.1016/j.jphotobiol.2014.04.010.
[27] CHEN Yuwei,SU Yulin,HU S H,et al.Functionalized graphene nanocomposites for enhancinng photothermal therapy in tumor treatment[J].Adv Drug Deliver Rev,2016,105:190-204.DOI:10.1016/j.addr.2016.05.022.
[28] TIAN Bo,WANG Chao,ZHANG Shuai,et al.Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide[J].ACS Nano,2011,5(9):7000-7009.DOI: 10.1021/nn201560b.
[29] YANG Kai,WAN Jianmei,ZHANG Shuai,et al.The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power[J].Biomaterials,2012,33(7):2206-2214.DOI:10.1016/j.biomaterials.2011.11.064.
[30] KALLURU P,VANKAYALA R,CHIANG C S,et al.Nano-graphene oxide-mediated in vivo fluorescence imaging and bimodal photodynamic and photo thermal destruction of tumors[J].Biomaterials,2016,95:1-10.DOI:10.1016/j.biomaterials.2016.04.006.
[31] 李勇,周非凡,陈伟.氧化石墨烯介导的光热免疫疗法治疗转移性小鼠乳腺肿瘤[J].生物化学与生物物理进展,2017,44(12):1095-1102.
[32] PENG Cheng,HU Wenbing,ZHOU Yuntao,et al.Intracellular imaging with a graphene-based fluorescent probe[J].Small,2010,6(15):1686-1692.DOI:10.1002/smll.201000560.
[33] HU Shanghsiu,CHEN Yuwei,HUNG Weiting,et al.Quantum-dot-tagged reduced graphene oxide nanocomposites for bright fluorescence bioimaging and photothermal therapy monitored in situ[J].Adv Mater,2012,24(13):1748-1754.DOI:10.1002/adma.201104070.
[34] GUPTA A,WOODS M D,LLLINGWORTH K D,et al.Single walled carbon nanotube composites for bone tissue engineering[J].J Orthop Res,2013,31(9):1374-1381.DOI:10.1002/jor.22379.
[35] PAN Lanlan,PEI Xibo,HE Rui,et al.Multiwall carbon nanotubes/polycaprolactone composites for bone tissue engineering application[J].Colloids Surf B Biointerfaces,2012,93(1):226-234.DOI:10.1016/j.colsurfb.2012.01.011.
[36] CROWDER S W,PRASAI D,RATH R,et al.Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells[J].Nanoscale,2013,5(10):4171-4176.DOI:10.1039/C3NR00803G.
[37] LA W G,PARK S,YOON H H,et al.Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide[J].Small,2013,9(23):4051-4060.DOI:10.1002/smll.201300571.
[38] STOUT D A,BASU B,WEBSTER T J.Poly(lactic-co-glycolic acid): Carbon nanofiber composites for myocardial tissue engineering applications[J].Acta Biomaterialia,2011,7(8):3101-3112.DOI:10.1016/j.actbio.2011.04.028.
[39] 熊兴泉,徐林建.碳纳米材料的无铜点击功能化[J].华侨大学学报(自然科学版),2015,36(6):677-682.DOI:10.11830/ISSN.1000-5013.2015.06.0677.
　　

相似文献/References:

[1]方艳红,连慧婷,陈国华.石墨烯/壳聚糖修饰玻碳电极测定水样中痕量铜离子[J].华侨大学学报(自然科学版),2011,32(5):529.[doi:10.11830/ISSN.1000-5013.2011.05.0529]
　FANG Yan-hong,LIAN Hui-ting,CHEN Guo-hua.Determination of Copper with Graphene Nanoplatelets-Chitosan Modified Glassy Carbon Electrode[J].Journal of Huaqiao University(Natural Science),2011,32(6):529.[doi:10.11830/ISSN.1000-5013.2011.05.0529]
[2]孙兆辉,连惠婷,孙向英,等.石墨烯掺杂对分子印迹电化学传感器的增敏作用[J].华侨大学学报(自然科学版),2012,33(4):401.[doi:10.11830/ISSN.1000-5013.2012.04.0401]
　SUN Zhao-hui,LIAN Hui-ting,SUN Xiang-ying,et al.Sensitivity Enhancement of Graphene Doped Molecular Imprinting Electrochemical Sensors[J].Journal of Huaqiao University(Natural Science),2012,33(6):401.[doi:10.11830/ISSN.1000-5013.2012.04.0401]
[3]周丰,连惠婷,曹学功,等.掺杂石墨烯分子印迹传感器对色氨酸的手性识别[J].华侨大学学报(自然科学版),2012,33(5):528.[doi:10.11830/ISSN.1000-5013.2012.05.0528]
　ZHOU Feng,LIAN Hui-ting,CAO Xue-Gong,et al.Enantioselective Recognition of Tryptophan Enantiomers by Graphene Doped Molecularly Imprinted Electrochemical Sensor[J].Journal of Huaqiao University(Natural Science),2012,33(6):528.[doi:10.11830/ISSN.1000-5013.2012.05.0528]
[4]解一诺,李逸鑫,王远鹏.微生物-电极修饰及影响电合成转化CO2过程的研究进展[J].华侨大学学报(自然科学版),2024,45(5):559.[doi:10.11830/ISSN.1000-5013.202407014]
　XIE Yinuo,LI Yixin,WANG Yuanpeng.Advances in Microbial-Electrode Modification and Influence on Process of Electrosynthesis to Convert CO2[J].Journal of Huaqiao University(Natural Science),2024,45(6):559.[doi:10.11830/ISSN.1000-5013.202407014]

备注/Memo

备注/Memo:
收稿日期: 2017-05-18
通信作者: 庞素秋(1972-),女,副主任药师,博士,主要从事医院药学、临床药学和天然药物的研究.E-mail:pangsuqiu@hqu.edu.cn.
基金项目: 国家自然科学基金资助项目(81371669, U1405215); 福建省泉州市科技计划项目(0712Z)
更新日期/Last Update: 2018-11-20