[1]彭俊纯,刁勇,李招发,等.宿主细胞DNA损伤反应与重组腺相关病毒载体基因表达[J].华侨大学学报(自然科学版),2014,35(5):564-569.[doi:10.11830/ISSN.1000-5013.2014.05.0564]
　PENG Jun-chun,DIAO Yong,LI Zhao-fa,et al.Interplay between DNA-Damage Response and Recombinant Adeno-Associated Virus Vector in Host Cells[J].Journal of Huaqiao University(Natural Science),2014,35(5):564-569.[doi:10.11830/ISSN.1000-5013.2014.05.0564]
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宿主细胞DNA损伤反应与重组腺相关病毒载体基因表达()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第35卷
期数:
2014年第5期
页码:
564-569
栏目:
出版日期:
2014-09-20

文章信息/Info

Title:
Interplay between DNA-Damage Response and Recombinant Adeno-Associated Virus Vector in Host Cells
文章编号:
1000-5013(2014)05-0564-06
作者:
彭俊纯;  刁勇;  李招发;  王启钊;  吕颖慧
华侨大学 生物医学学院, 福建 厦门 361021
Author(s):
PENG Jun-chun;  DIAO Yong;  LI Zhao-fa;  WANG Qi-zhao;  LYU Ying-hui
School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
关键词:
腺相关病毒;  基因治疗;  DNA损伤修复;  基因打靶
Keywords:
adeno-associated virus;  gene therapy;  DNA damage repair;  gene targeting
分类号:
Q78
DOI:
10.11830/ISSN.1000-5013.2014.05.0564
文献标志码:
A
摘要:
文中主要讨论细胞DNA修复机制与重组腺相关病毒(recombinant adeno-associated virus,rAAV)载体的相互关系,探讨通过调节宿主细胞DNA修复机制,提高rAAV载体表达及基因打靶效率的方法,进而提高rAAV载体基因表达的可能性.
Abstract:
The article mainly discusses the connection between the mechanism of DNA repair in cells and the recombinant AAV(rAAV)vectors, and explores the methods for improving the efficiency of rAAV vectors expression and gene targeting by regulating the mechanism of DNA repair in host cells, thus more likely to increase the rAAV vectors gene expression.

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备注/Memo

备注/Memo:
收稿日期: 2013-12-17
通信作者: 刁勇(1967-),男,教授,主要从事基因治疗的研究.E-mail:diaoyong@hqu.edu.cn.
基金项目: 国家国际科技合作专项项目(2011DFG33320); 国家自然科学基金资助项目(81371669, 81271691, 81201183); 福建省自然科学基金资助项目(2012J01397)
更新日期/Last Update: 2014-09-20