[1]韩磊,乔爱敏,刘青.天麻素的抗糖尿病作用实验[J].华侨大学学报(自然科学版),2013,34(6):682-686.[doi:10.11830/ISSN.1000-5013.2013.06.0682]
　HAN Lei,QIAO Ai-min,LIU Qing.Research on Anti-Diabetic Efficacy of Gastrodin[J].Journal of Huaqiao University(Natural Science),2013,34(6):682-686.[doi:10.11830/ISSN.1000-5013.2013.06.0682]
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天麻素的抗糖尿病作用实验()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第34卷
期数:
2013年第6期
页码:
682-686
栏目:
出版日期:
2013-11-20

文章信息/Info

Title:
Research on Anti-Diabetic Efficacy of Gastrodin
文章编号:
1000-5013(2013)06-0682-05
作者:
韩磊;  乔爱敏;  刘青
华侨大学 化工学院, 福建 厦门 361021
Author(s):
HAN Lei;  QIAO Ai-min;  LIU Qing
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
关键词:
天麻素;  糖尿病;  血糖;  血脂;  抗氧化
Keywords:
gastrodin;  diabetes;  blood glucose;  blood lipid;  antioxidant
分类号:
R285.5;R587.1
DOI:
10.11830/ISSN.1000-5013.2013.06.0682
文献标志码:
A
摘要:
分离、培养人脐静脉内皮细胞(HUVECs),测定在高糖刺激下胞外乳酸脱氢酶(LDH)的活性,并用链脲佐菌素建立糖尿病小鼠模型,分别以不同天麻素质量浓度干预14 d进行试验.研究结果表明:天麻素能降低高糖刺激下HUVECs胞外LDH的活性,减轻高糖对血管内皮细胞造成的损伤;天麻素能显著降低糖尿病小鼠的血糖,降低小鼠血清中甘油三酯、总胆固醇及丙二醛浓度,提高超氧化物歧化酶(SOD)的活性,显示出明显的抗糖尿病作用.
Abstract:
The human umbilical vein endothelial cells(HUVECs)were separated and cultivated. The lactate dehydrogenase(LDH)activity in damaged HUVECs stimulated by high glucose was then determined. The anti-diabetic experiment in vivo was performed on streptozotocin(STZ)-induced diabetic mice, and the diabetic mice were treated with gastrodin(12.5, 25 and 50 mg·kg- 1)for 14d. The results showed that the gastrodin could decrease the extracellular LDH activity of HUVECs and reduce the damage of endothelial cells under high glucose. Moreover, gastrodine could decrease the blood glucose of diabetes mice significantly, and the serum triglyceride(TG), the content of total cholesterol(TC), and the malondialdehyde(MDA)content were all decreased. It also improved the super oxide dismutase(SOD)activity in diabetic mice serum. Therefore, it can be concluded that the gastrodin has an obvious anti-diabetic effect in the STZ-induced diabetic mouse model.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2013-01-19
通信作者: 刘青(1970-),女,博士,副教授,主要从事药理学的研究.E-mail:liuq@hqu.edu.cn.
基金项目: 福建省自然科学基金资助项目(2013J01337); 华侨大学侨办科研基金资助项目(10QZR15); 华侨大学教学改革科研基金资助项目(66661222Y)
更新日期/Last Update: 2013-11-20