[1]刘青,薛秀玲,叶静,等.纳米二氧化钛对小鼠肺、脑和肝脏组织的影响[J].华侨大学学报(自然科学版),2009,30(2):179-182.[doi:10.11830/ISSN.1000-5013.2009.02.0179]
　LIU Qing,XUE Xiu-ling,YE Jing,et al.The Effects of Nanometer-Sized Titanium Dioxide on the Brains,Lungs and Livers of Mice[J].Journal of Huaqiao University(Natural Science),2009,30(2):179-182.[doi:10.11830/ISSN.1000-5013.2009.02.0179]
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纳米二氧化钛对小鼠肺、脑和肝脏组织的影响()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第30卷
期数:
2009年第2期
页码:
179-182
栏目:
出版日期:
2009-03-20

文章信息/Info

Title:
The Effects of Nanometer-Sized Titanium Dioxide on the Brains,Lungs and Livers of Mice
文章编号:
1000-5013(2009)02-0179-04
作者:
刘青; 薛秀玲; 叶静; 张宏
华侨大学化工学院
Author(s):
LIU Qing;  XUE Xiu-ling;  YE Jing;  ZHANG Hong
College of Chemical Engineering, Huaqiao University, Quanzhou 362021, China
关键词:
纳米二氧化钛;  脑组织;  肺组织;  肝脏;  氧化损伤
Keywords:
nanometer-sized titanium dioxide;  brain;  lung;  liver;  oxidative damage
分类号:
R114
DOI:
10.11830/ISSN.1000-5013.2009.02.0179
文献标志码:
A
摘要:
研究不同剂量的纳米二氧化钛颗粒对小鼠肺、脑及肝脏组织的影响.给小鼠一次性腹腔注射不同剂量的纳米二氧化钛颗粒溶液,14 d后测定小鼠脑、肺组织中的超氧化物歧化酶(SOD)和还原型谷胱甘肽过氧化物酶(GPX)、过氧化氢酶(CAT)的活性及丙二醛(MDA)的浓度,并测定肝脏中谷草转氨酶(GOT)及谷丙转氨酶(GPT)的活性.结果表明,给予纳米二氧化钛颗粒后,小鼠肺及脑组织中的抗氧化酶——SOD,GPX和CAT的活性及MDA浓度都呈现出一定的变化.肝脏中GOT,GPT的活性显著增高.纳米二氧化钛颗粒对肝脏有一定损害作用,并能造成脑、肺组织的氧化防御体系失衡,使抗氧化酶活性及比例失调,氧化损伤程度因组织器官的不同而不同.
Abstract:
Studies were carried out on the effects of the different concentration of nanometer-sized titanium dioxide on the brains,lungs and livers of mice.The nanometer-sized titanium dioxide of different concentration was injected into the abdominal cavity of mice.The activities of superoxide dismutase(SOD),glutathione peroxidase(GPX),catalase(CAT) and the contents of maleic dialdehyde(MDA) in the brains and lungs of mice were determined after 14 days.At the same time glutamic-oxaloacetic transaminase(GOP) and glutamic-pyruvic transaminase(GPT) were examined in the livers of mice.The activities of SOD,GPX,CAT and the contents of MDA in the brains and lungs of mice all displayed certain changes.The activities of GOP and GTP increased obviously.The livers of mice were impaired after the nanometer-sized titanium dioxide was administered and the system of antioxidant defenses became imbalance.The activities and the proportions of antioxidases were disregulated and caused certain oxidation damages to the brains and lungs of mice.But such damages vary from organs.

参考文献/References:

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备注/Memo

备注/Memo:
福建省自然科学基金资助项目(2006J0113); 华侨大学科研基金资助项目(05BS301)
更新日期/Last Update: 2014-03-23