[1]刘玮炜,唐丽娟,赵跃强,等.4-[1,2,4]三氮唑-1-基甲基苯腈的合成[J].华侨大学学报(自然科学版),2009,30(2):158-160.[doi:10.11830/ISSN.1000-5013.2009.02.0158]
　LIU Wei-wei,TANG Li-juan,ZHAO Yue-qiang,et al.Synthesis of 4-[1,2,4] Triazol-1-Ylmethyl-Benzonitrile[J].Journal of Huaqiao University(Natural Science),2009,30(2):158-160.[doi:10.11830/ISSN.1000-5013.2009.02.0158]
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4-[1,2,4]三氮唑-1-基甲基苯腈的合成()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第30卷
期数:
2009年第2期
页码:
158-160
栏目:
出版日期:
2009-03-20

文章信息/Info

Title:
Synthesis of 4-[1,2,4] Triazol-1-Ylmethyl-Benzonitrile
文章编号:
1000-5013(2009)02-0158-03
作者:
刘玮炜; 唐丽娟; 赵跃强; 曾艳霞
淮海工学院化学工程系
Author(s):
LIU Wei-wei;  TANG Li-juan;  ZHAO Yue-qiang;  ZENG Yan-xia
Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China
关键词:
4-[1; 2; 4]三氮唑-1-基甲基苯腈;  对氰基氯苄;  1H-[1; 2; 4]三氮唑;  N-烃基化;  工艺条件
Keywords:
4-[1; 2; 4] triazol-1-ylmethylbenzonitrile;  4-(chloromethyl) ben-zonitrile;  1H-[1; 2; 4]triazole;  N-hydrocarbylation;  reaction condition
分类号:
TQ463.53
DOI:
10.11830/ISSN.1000-5013.2009.02.0158
文献标志码:
A
摘要:
改进4-[1,2,4]三氮唑-1-基甲基苯腈的合成方法,以价廉易得的对氰基氯苄代替对氰基溴苄,研究对氰基氯苄与1H-[1,2,4]三氮唑的N-烃基化反应及合成4-[1,2,4]三氮唑-1-基甲基苯腈的工艺条件.实验所选用的最佳工艺条件:对氰基氯苄为0.03 mol,1H-[1,2,4]三氮唑用量为0.045 mol,乙腈溶剂为20 mL,混合碱(无水碳酸钾和氢氧化钾的量比为1∶1)的总用量为0.03 mol,反应温度为70℃,反应时间为5 h,在此条件下,4-[1,2,4]三氮唑-1-基甲基苯腈的收率可达76%.
Abstract:
Synthesis method of 4-[1,2,4] triazol-1-ylmethyl-benzonitrile was improved by using the cheaper 4-(chloromethyl) ben-zonitrile instead of 4-(bromomethyl) ben-zonitrile as the raw material.Reaction conditions for the preparation of 4-[1,2,4] triazol-1-ylmethyl-benzonitrile from 4-(chloromethyl) ben-zonitrile and 1H- triazole by N-hydrocarbylation were investigated.The experimental results indicated that the optimal reaction conditions are as follow: 4-(chloromethyl) ben-zonitrile 0.03 mol,1H-[1,2,4] triazole 0.045 mol,acetonitrile solvent 20 mL,the mixed base(anhydrous K2CO3∶KOH=1∶1) 0.03 mol,temperature 70 ℃ and reaction time 5 h; under this reaction condition,the yield of the objective compound can reach 76%.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(20672090); 江苏省海洋生物技术重点建设实验室科研基金资助项目(2006HS014); 江苏省“六大人才高峰”项目(07-A-024); 淮海工学院学科建设科研基金资助项目(XK2003011)
更新日期/Last Update: 2014-03-23