[1]刘源岗,罗丙红,周长忍.新型生物降解交联剂的合成及应用(英文)[J].华侨大学学报(自然科学版),2007,28(4):394-398.[doi:10.3969/j.issn.1000-5013.2007.04.016]
　LIU Yuan-gang,LUO Bing-hong,ZHOU Chang-ren.Synthesis and Application of Biodegradable Crosslinking Agent[J].Journal of Huaqiao University(Natural Science),2007,28(4):394-398.[doi:10.3969/j.issn.1000-5013.2007.04.016]
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新型生物降解交联剂的合成及应用(英文)()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第28卷
期数:
2007年第4期
页码:
394-398
栏目:
出版日期:
2007-10-20

文章信息/Info

Title:
Synthesis and Application of Biodegradable Crosslinking Agent
文章编号:
1000-5013(2007)04-0394-05
作者:
刘源岗; 罗丙红; 周长忍
华侨大学材料科学与工程学院; 暨南大学生物材料研究室; 暨南大学生物材料研究室 福建泉州362021; 广东广州510632
Author(s):
LIU Yuan-gang1;  LUO Bing-hong2;  ZHOU Chang-ren2
1.College of Materials Science and Engineering, Huaqiao University, Quanzhou 362021, China 2.Laboratory of Biomaterials Research, Jinan University, Guangzhou 510632, China
关键词:
交联剂;  乙烯基吡咯烷酮;  羟乙基甲基丙烯酸酯封端聚乳酸;  膜;  两亲性;  生物降解
Keywords:
crosslinking agent;  NVP;  HEMA-PLA;  film;  amphiphilic;  biodegradable
分类号:
R318.08
DOI:
10.3969/j.issn.1000-5013.2007.04.016
文献标志码:
A
摘要:
制备出新型两亲性可生物降解聚合物膜.膜由3种成分组成,其一为新型的可生物降解交联剂,用以调节膜的降解速率; 其二为亲水单体乙烯基吡咯烷酮,用以提高材料的亲水性,并最终提高材料与细胞的相互作用; 其三为羟乙基甲基丙烯酸酯封端聚乳酸,用以调节膜的机械强度,通过傅里叶红外光谱(FTIR)和核磁共振(NMR)分析,结果表明,成功合成可生物降解的交联剂及大分子单体HEMA-PLA,并制备出可应用于组织工程的新型膜材料.
Abstract:
A novel kind of amphiphilic and biodegradable films were developed.The film mainly is composed of three components: a novel biodegradable crosslinking agent,which is used to adjust the degradable rate of the film; a hydrophilic monomer N-vinyl pyrrolidone(NVP),which is used to improve the material′s hydrophilicity,and ultimately improve the interaction between material and cells; a macromonomer 2-hydroxyethyl methacrylate-terminated polylactide acid(HEMA-PLA),which is used to control the film′s mechanical strength.These films hopefully will have practical applications in tissue engineering.

备注/Memo

备注/Memo:
国家重大基础研究(973)项目子课题(G199054306); 福建省青年科技人才创新项目(2006F3079); 华侨大学高层次人才科研启动项目(06BS215)
更新日期/Last Update: 2014-03-23