[1]杨素心,马丽浩,张景红.参与肺癌靶向耐药的lncRNAs的作用及其机制[J].华侨大学学报(自然科学版),2025,46(4):369-378.[doi:10.11830/ISSN.1000-5013.202504010]
 YANG Suxin,MA Lihao,ZHANG Jinghong.Role of LncRNAs in Targeted Drug Resistance in Lung Cancer and Their Mechanisms[J].Journal of Huaqiao University(Natural Science),2025,46(4):369-378.[doi:10.11830/ISSN.1000-5013.202504010]
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参与肺癌靶向耐药的lncRNAs的作用及其机制()
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《华侨大学学报(自然科学版)》[ISSN:1000-5013/CN:35-1079/N]

卷:
第46卷
期数:
2025年第4期
页码:
369-378
栏目:
出版日期:
2025-07-16

文章信息/Info

Title:
Role of LncRNAs in Targeted Drug Resistance in Lung Cancer and Their Mechanisms
文章编号:
1000-5013(2025)04-0369-10
作者:
杨素心12 马丽浩1 张景红1
1. 华侨大学 医学院, 福建 厦门 361021;2. 马德里康普顿斯大学 社会学院, 马德里 28040
Author(s):
YANG Suxin12 MA Lihao1 ZHANG Jinghong1
1. School of Medicine, Huaqiao University, Xiamen 361021, China; 2. School of Sociology, Universidad Complutense de Madrid, Madrid 28040, Spain
关键词:
长链非编码RNAs(lncRNAs) 肺癌 顺铂耐药 靶向耐药 分子机制
Keywords:
long non-coding RNAs(lncRNAs) lung cancer cisplatin resistance targeted drug resistance molecular mechanism
分类号:
R979.1;R966
DOI:
10.11830/ISSN.1000-5013.202504010
文献标志码:
A
摘要:
对参与肺癌靶向耐药的长链非编码RNAs(lncRNAs)的作用及其机制进行综合分析,阐明治疗肺癌耐药的多种标志物。通过查阅近年相关文献,总结参与肺癌顺铂(DDP)耐药、靶向表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)抵抗、靶向间变性淋巴瘤激酶酪氨酸激酶抑制剂(ALK-TKIs)抵抗,以及免疫治疗抵抗的各种长链非编码RNAs,分析其在逆转肺癌耐药中的作用和贡献。结果表明:在参与EGFR-TKIs靶向抵抗的lncRNAs中,LINC00460不仅通过激活miR-338-3p/小染色体维持蛋白4通路调控吉非替尼耐药,而且在奥西替尼耐药中同样发挥关键作用,而肺腺癌转移相关转录本1则通过调控主要组织相容性复合体蛋白和程序性死亡配体1的表达,进而影响免疫细胞群的耐药,其有望成为改善肺癌免疫治疗预后的关键靶点。
Abstract:
The roles and mechanisms of long non-coding RNAs(lncRNAs)involved in targeted drug resistance in lung cancer were analyzed comprehensively, elucidating multiple biomarkers for treating lung cancer resistance. By reviewing relevant literature in recent years, the involvement in cisplatin(DDP)resistance in lung cancer, targeted epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)resistance, targeted anaplastic lymphoma kinase tyrosine kinase inhibitors(ALK-TKIs)resistance, and various long non-coding RNAs(lncRNAs)resistant to immunotherapy were summarized, and its role and contribution in reversing drug resistance in lung cancer were analyzed. The results show that among the lncRNAs associated with EGFR-TKIs targeted resistance, LINC00460 not only regulates gefitinib resistance through activation of the miR-338-3p/SMC4 pathway, but also plays a crucial role in resistance to osimertinib. Additionally, lung adenocarcinoma metastasis-associated transcript 1 has been shown to affect immune resistance by modulating the expression of major histocompatibility complex proteins and programmed death-ligand 1, highlighting its potential as a key therapeutic target for improving the outcomes of immunotherapy in lung cancer.

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备注/Memo

备注/Memo:
收稿日期: 2025-04-19
通信作者: 张景红(1966-),女,教授,博士,主要从事肿瘤药理学的研究。E-mail:zjh@hqu.edu.cn。
基金项目: 福建省科技计划引导性项目(2018Y0062); 福建省厦门市自然科学基金面上资助项目(3502Z202373044)https://hdxb.hqu.edu.cn/
更新日期/Last Update: 2025-07-20