[1]许晓英,虞文熙,孙源培,等.虾青素微囊粉的制备与质量评价及其初步药代动力学[J].华侨大学学报(自然科学版),2025,46(3):288-295.[doi:10.11830/ISSN.1000-5013.202410006]
　XU Xiaoying,YU Wenxi,SUN Yuanpei,et al.Preparation, Quality Evaluation of Astaxanthin Microcapsule Powder and Its Preliminary Pharmacokinetics[J].Journal of Huaqiao University(Natural Science),2025,46(3):288-295.[doi:10.11830/ISSN.1000-5013.202410006]
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虾青素微囊粉的制备与质量评价及其初步药代动力学()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第46卷
期数:
2025年第3期
页码:
288-295
栏目:
出版日期:
2025-05-20

文章信息/Info

Title:
Preparation, Quality Evaluation of Astaxanthin Microcapsule Powder and Its Preliminary Pharmacokinetics
文章编号:
1000-5013(2025)03-0288-08
作者:
许晓英1;  虞文熙1;  孙源培1;  王之2;  王立强1;  侯志勇1; 3
1. 华侨大学 生物医学学院, 福建 泉州 362021;2. 陆军军医大学 第二附属医院, 重庆 400037;3. 解放军962医院, 黑龙江 哈尔滨 150080
Author(s):
XU Xiaoying1;  YU Wenxi1;  SUN Yuanpei1;  WANG Zhi2;  WANG Liqiang1;  HOU Zhiyong1; 3
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. The Second Affiliated Hospital, Army Medical University, Chongqing 400037, China; 3. PLA 962 Hospital, Harbin 150080, China
关键词:
虾青素微囊粉;  喷雾干燥;  雨生红球藻油;  质量评价;  药代动力学
Keywords:
astaxanthin microcapsule powder;  spray drying;  haematococcus pluvialis oil;  quality evaluation;  pharmacokinetics
分类号:
R94
DOI:
10.11830/ISSN.1000-5013.202410006
文献标志码:
A
摘要:
采用喷雾干燥法制备虾青素微囊粉(Asta-MCs),对Asta-MCs的外观、粒径、质量分数、含水量、溶解度、包封率、载药量和休止角等指标进行质量评价,并进行体内药代动力学研究。结果表明:Asta-MCs为橙红色粉末,理化性能良好;自制Asta-MCs的半衰期为(15.523±3.079)h,平均滞留时间为(17.787±0.108)h,达峰质量浓度为(1.191±0.060)μg·mL-1,达峰时间为8 h,血药质量浓度-时间曲线下面积(AUC0~t)为(26.874±2.198)μg·h·mL-1,相对生物利用度达到182.32%;相较于雨生红球藻油和市售Asta-MCs,自制Asta-MCs的药代动力学参数有显著提升。
Abstract:
Astaxanthin microcapsule powder(Asta-MCs)was prepared by spray drying method. The quality of Asta-MCs was evaluated by parameters such as appearance, particle size, mass fraction, water content, solubility, encapsulation efficiency, drug loading and angle of repose, and pharmacokinetic studies in vivo were also carried out. The results showed that Asta-MCs were orange-red powders with good physicochemical properties. For the self-made Asta-MCs, the half-life was(15.523±3.079)h, the average retention time was(17.787±0.108)h, the peak mass concentration was(1.191±0.060)μg·mL-1, the peak time was 8 h, the area under the blood drug mass concentration-time curve(AUC0~t)was(26.874±2.198)μg·h·mL-1, and the relative bioavailability reached 182.32%. Compared with haematococcus pluvialis oil and commercially available Asta-MCs, the pharmacokinetic parameters of the self-made Asta-MCs were significantly improved.

参考文献/References:

[1] 裘晖,朱晓立.虾青素的结构与功能[J].食品工程,2007(1):16-18.DOI:10.3969/j.issn.1673-6044.2007.01.006.
[2] FARAONE I,SINISGALLI C,OSTUNI A,et al.Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review[J].Pharmacological Research,2020,155:104689.DOI:10.1016/j.phrs.2020.104689.
[3] ZHENG Xinxin,HUANG Qing.Assessment of the antioxidant activities of representative optical and geometric isomers of astaxanthin against singlet oxygen in solution by a spectroscopic approach[J].Food Chemistry,2022,395:133584.DOI:10.1016/j.foodchem.2022.133584.
[4] GUERRA B A,OTTON R.Impact of the carotenoid astaxanthin on phagocytic capacity and ROS/RNS production of human neutrophils treated with free fatty acids and high glucose[J].International Immunopharmacology,2011,11(12):2220-2226.DOI:10.1016/j.intimp.2011.10.004.
[5] NISHIDA Y,NAWAZ A,HECHT K,et al.Astaxanthin as a novel mitochondrial regulator: A new aspect of carotenoids, beyond antioxidants[J].Nutrients,2022,14(1):107.DOI:10.3390/nu14010107.
[6] RIZZARDI N,PEZZOLESI L,SAMORI C,et al.Natural astaxanthin is a green antioxidant able to counteract lipid peroxidation and ferroptotic cell death[J].International Journal of Molecular Sciences,2022,23(23):15137.DOI:10.3390/ijms232315137.
[7] KOHANDEL Z,FARKHONDEH T,ASCHNER M,et al.Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases[J].Biomedicine & Pharmacotherapy,2022,145:112179.DOI:10.1016/j.biopha.2021.112179.
[8] LIM K C,YUSOFF F M,SHARIFF M,et al.Astaxanthin as feed supplement in aquatic animals[J].Reviews in Aquaculture,2018,10(3):738-773.DOI:10.1111/raq.12200.
[9] ZHANG Congqiang,CHEN Xixian,TOO H-P.Microbial astaxanthin biosynthesis: Recent achievements, challenges, and commercialization outlook[J].Applied Microbiology and Biotechnology,2020,104(13):5725-5737.DOI:10.1007/s00253-020-10648-2.
[10] 李浩明,高蓝.虾青素的结构、功能与应用[J].精细化工,2003,20(1):32-37.DOI:10.3321/j.issn:1003-5214.2003.01.011.
[11] MENG Weihao,SUN Hongnan,MU Taihua,et al.Chitosan-based Pickering emulsion: A comprehensive review on their stabilizers, bioavailability, applications and regulations[J].Carbohydrate Polymers,2023,304:120491.DOI:10.1016/j.carbpol.2022.120491.
[12] YAN C,KIM S-R.Microencapsulation for pharmaceutical applications: A review[J].ACS Applied Bio Materials,2024,7(2):692-710.DOI:10.1021/acsabm.3c00776.
[13] KWON O S,JANG J,BAE J.A review of fabrication methods and applications of novel tailored microcapsules[J].Current Organic Chemistry,2013,17(1):3-13.DOI:10.2174/138527213805289196.
[14] SU Ya,CHEN Yingchen,ZHANG Lizhang,et al.Synthesis and characterization of lotus seed protein-based curcumin microcapsules with enhanced solubility, stability, and sustained release[J].Journal of the Science of Food and Agriculture,2022,102(6):2220-2231.DOI:10.1002/jsfa.11560.
[15] NIIZAWA I,ESPINACO B Y,ZORRILLA S E,et al.Natural astaxanthin encapsulation: Use of response surface methodology for the design of alginate beads[J].International Journal of Biological Macromolecules,2019,121:601-608.DOI:10.1016/j.ijbiomac.2018.10.044.
[16] POTROZ M G,MUNDARGI R C,GILLISSEN J J,et al.Plant-based hollow microcapsules for oral delivery applications: Toward optimized loading and controlled release[J].Advanced Functional Materials,2017,27(31):1700270.DOI:10.1002/adfm.201700270.
[17] KOREDDI H,SURYADEVARA V,TALAMANCHI B,et al.Design and evaluation of bosentan controlled-release microcapsules[J].International Journal of Applied Pharmaceutics,2022,14(2):87-94.DOI:10.22159/ijap.2022v14i2.43730.
[18] LI Dahu,WU Houjiu,DOU Huating.Weight loss effect of sweet orange essential oil microcapsules on obese SD rats induced by high-fat diet[J].Bioscience, Biotechnology, and Biochemistry,2019,83(5):923-932.DOI:10.1080/09168451.2019.1578640.
[19] KIDD P.Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential[J].Alternative Medicine Review,2011,16(4):355-364.DOI:10.1016/j.peptides.2011.09.020.
[20] PAN Li,WANG Hongyan, GU Keren.Nanoliposomes as vehicles for astaxanthin: Characterization, in vitro release evaluation and structure[J].Molecules,2018,23(11):2822.DOI:10.3390/molecules23112822.
[21] XU Yan,JIA Zhe,WANG Jiaxing,et al.Property and stability of astaxanthin emulsion based on Pickering emulsion templating with zein and sodium alginate as stabilizer[J].International Journal of Molecular Sciences,2022,23(16):9386.DOI:10.3390/ijms23169386.
[22] HOANG T M H,HO T O,QUACH T Q,et al.Astaxanthin-loaded nanoparticles enhance its cell uptake, antioxidant and hypolipidemic activities in multiple cell lines[J].Journal of Drug Delivery Science and Technology,2023,80:104133.DOI:10.1016/j.jddst.2022.104133.

备注/Memo

备注/Memo:
收稿日期: 2024-10-14
通信作者: 侯志勇(1972-),男,副主任药师,主要从事创新药物的研究。E-mail:mpp5358@163.com。
基金项目: 国家重点研发计划项目(2016YFE0101700); 福建省高校产学合作重大项目(2019Y4007); 华侨大学研究生科研创新基金资助项目(18013071019)https://hdxb.hqu.edu.cn/
更新日期/Last Update: 2025-05-20