[1]成志云,谭泳仪,白如玉,等.MEI1基因在宫颈癌组织中的表达和临床意义[J].华侨大学学报(自然科学版),2025,46(3):283-287.[doi:10.11830/ISSN.1000-5013.202412004]
　CHENG Zhiyun,TAN Yongyi,BAI Ruyu,et al.Expression and Clinical Significance of MEI1 Gene in Cervical Cancer Tissues[J].Journal of Huaqiao University(Natural Science),2025,46(3):283-287.[doi:10.11830/ISSN.1000-5013.202412004]
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MEI1基因在宫颈癌组织中的表达和临床意义()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第46卷
期数:
2025年第3期
页码:
283-287
栏目:
出版日期:
2025-05-20

文章信息/Info

Title:
Expression and Clinical Significance of MEI1 Gene in Cervical Cancer Tissues
文章编号:
1000-5013(2025)03-0283-05
作者:
成志云;  谭泳仪;  白如玉;  刁勇
华侨大学 医学院, 福建 泉州 363021
Author(s):
CHENG Zhiyun;  TAN Yongyi;  BAI Ruyu;  DIAO Yong
School of Medicine, Huaqiao University, Quanzhou 362021, China
关键词:
MEI1基因;  宫颈癌;  标志物;  临床意义
Keywords:
MEI1 gene;  cervical cancer;  biomarker;  clinical significance
分类号:
R737.33
DOI:
10.11830/ISSN.1000-5013.202412004
文献标志码:
A
摘要:
基于生物信息学方法分析减数分裂双链断裂形成蛋白1(MEI1)基因在宫颈癌(CCA)发生发展过程中的表达变化,评估其表达与CCA患者的预后和免疫浸润相关性。通过GEPIA及HPA数据库分析MEI1基因在CCA组织中的表达情况,通过Timer数据库分析MEI1基因与免疫细胞的浸润水平的关系,通过String数据库对MEI1的相互作用蛋白网络进行分析。结果表明:在基因转录及蛋白表达水平上,与正常组织相比,MEI1在CCA组织中的表达显著增加;MEI1基因的高表达水平与CCA患者预后呈正相关,MEI1基因的表达越高,预后越好;MEI1基因的表达水平与中性粒细胞、树突状细胞、B细胞、CD4细胞和CD8细胞的免疫浸润水平均呈正相关,MEI1可能通过与NEDD8、MORC1、MEI4、REC114、SPO11、C11orf80、HORMAD1、CCDC36、ANKRD31、SYCE1等蛋白的相互作用调控CCA的发生发展。
Abstract:
Based on bioinformatics methods, the expression changes of meiotic double-stranded break formation protein1(MEI1)gene during the occurrence and development of cervical cancer(CCA)were analyzed, and the correlation between its expression and the prognosis of CCA patients as well as immune infiltration was evaluated. The expression of MEI1 gene in CCA tissues was analyzed through the GEPIA and HPA databases. The relationship between the expression of MEI1 gene and the infiltration levels of immune cells was analyzed through the Timer database. The interaction protein network of MEI1 was analyzed through the String database. The results showed that at the levels of gene transcription and protein expression, compared with normal tissues, the expression of MEI1 was significantly increased in CCA tissues. The high expression level of MEI1 gene was positively correlated with the prognosis of CCA patients, the higher the expression of MEI1 gene, the better the prognosis. The expression level of MEI1 gene was positively correlated with the immune infiltration levels of neutrophils, dendritic cells, B cells, CD4 cells and CD8 cells, MEI1 may regulate the occurrence and development of CCA through interactions with proteins such as NEDD8, MORC1, MEI4, REC114, SPO11, C11orf80, HORMAD1, CCDC36, ANKRD31 and SYCE1.

参考文献/References:

[1] 邱丽华,陈飞,赵卫东,等.2024子宫颈癌筛查和早期精准诊断现状白皮书[J].中国实用妇科与产科杂志,2024,40(1):85-95.DOI:10.19538/j.fk2024010118.
[2] WANG Lili,LIU Xiaoli,ZHANG Junhua,et al.Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions(CIN1/VaIN1)[J].Photodiagnosis and Photodyn Therapy,2022,39:103009.DOI:10.1016/j.pdpdt.2022.103009.
[3] TRIPATHI N,KESHARI S,SHAHI P,et al.Human papillomavirus elevated genetic biomarker signature by statistical algorithm[J].Journal of Cellular Physiology,2020,235(12):9922-9932.DOI:10.1002/jcp.29807.
[4] CHEN Xiaohang,LIU Yanan,LUO Xiaojin,et al.HPV16 E6-induced M2 macrophage polarization in the cervical microenvironment via exosomal miR-204-5p[J].Scientific Reports,2024,14(1):9922-9932.DOI:10.1038/s41598-024-74399-0.
[5] XU Jianze,GAO Jianing,LIU Junyan,et al.ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression[J].Cell Reports,2022,38(12):110540.DOI:10.1016/j.celrep.2022.110540.
[6] 崔迎迎,芒来,李蓓,等.MEI1基因可变剪切事件对蒙古马精子生成的调控作用[J].畜牧兽医学报,2022,53(4):1096-1108.DOI:10.27229/d.cnki.gnmnu.2021.001221.
[7] WU Xiangli,TIAN Yuqing,YU Yiqi,et al.Novel MEI1 mutations cause chromosomal and DNA methylation abnormalities leading to embryonic arrest and implantation failure[J].Molecular Genetics and Genomics,2024,299(1):18.DOI:10.1007/s00438-024-02113-w.
[8] ZHANG Liya,JIANG Yi,LU Xiaofan,et al.Genomic characterization of cervical cancer based on human papillomavirus status[J].Gynecology Oncology,2019,152(3):629-637.DOI:10.1016/j.ygyno.2018.12.017.
[9] 陈丽萍,贺晓琪.MEI1在宫颈癌中高表达并促进宫颈癌细胞的增殖与迁移侵袭[J].华中科技大学学报(医学版),2021,50(2):152-158.DOI:10.3870/j.issn.1672-0741.2021.02.003.
[10] LI Taiwen,FAN Jingyu,WANG Binbin,et al.TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells[J].Cancer Research,2017,77(21):E108-E110.DOI:10.1158/0008-5472.CAN-17-0307.
[11] 段远琼,尹如铁.子宫颈癌的免疫治疗进展[J].实用妇产科杂志,2024,40(10):769-773.
[12] 张清伟,尹如铁.宫颈癌诊治热点与进展[J].实用医学杂志,2024,40(17):2357-2362.DOI:10.3969/j.issn.1006-5725.2024.17.001.
[13] CHATTERJEE M,GUPTA S,MUKHERJEE T,et al.The role of extracellular vesicles in the pathogenesis of gynecological cancer[J].Frontiers in Oncology,2024,14:1477610.DOI:10.3389/fonc.2024.1477610.
[14] MUNDI S,MASSARO M,SCODITTI E,et al.Endothelial permeability, LDl deposition, and cardiovascular risk factors: A review[J].Cardiovascular Research,2018,114(1):35-52.DOI:10.1093/cvr/cvx226.
[15] DAI Guoyu,OU Jie,WU Bin.A predictive study of metabolism reprogramming in cervical carcinoma[J].Annals Translation Medicine,2022,10(7):414.DOI:10.21037/atm-22-981.
[16] QIU Ling,FENG Hao,YU Hailin,et al.Characterization of the genomic landscape in cervical cancer by next generation sequencing[J].Genes,2022,13(2):287.DOI:10.3390/genes13020287.

备注/Memo

备注/Memo:
收稿日期: 2024-12-09
通信作者: 刁勇(1967-),男,教授,博士,博士生导师,主要从事基因药物的研究。E-mail:diaoyong@hqu.edu.cn。
基金项目: 国家自然科学基金资助项目(20141ZA003); 福建省药理学会科技联合项目(2021FJYL007)https://hdxb.hqu.edu.cn/
更新日期/Last Update: 2025-05-20