[1]佟雷,吴梅,刘卓晟.坏死性凋亡在病毒感染性疾病中的研究进展[J].华侨大学学报(自然科学版),2025,46(3):241-247.[doi:10.11830/ISSN.1000-5013.202501026]
 TONG Lei,WU Mei,LIU Zhuosheng.Research Progress of Necrotic Apoptosis in Viral Infectious Diseases[J].Journal of Huaqiao University(Natural Science),2025,46(3):241-247.[doi:10.11830/ISSN.1000-5013.202501026]
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坏死性凋亡在病毒感染性疾病中的研究进展()
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《华侨大学学报(自然科学版)》[ISSN:1000-5013/CN:35-1079/N]

卷:
第46卷
期数:
2025年第3期
页码:
241-247
栏目:
出版日期:
2025-05-20

文章信息/Info

Title:
Research Progress of Necrotic Apoptosis in Viral Infectious Diseases
文章编号:
1000-5013(2025)03-0241-07
作者:
佟雷 吴梅 刘卓晟
华侨大学 医学院, 福建 泉州 362021
Author(s):
TONG Lei WU Mei LIU Zhuosheng
College of Medicine, Huaqiao University, Quanzhou 362021, China
关键词:
坏死性凋亡 病毒 程序性细胞死亡 活性氧
Keywords:
necrotic apoptosis virus programmed cell death active oxygen
分类号:
R373
DOI:
10.11830/ISSN.1000-5013.202501026
文献标志码:
A
摘要:
坏死性凋亡是一种受调控的细胞死亡方式,通常由死亡受体与肿瘤坏死因子结合引发,或病毒感染引发。与细胞凋亡不同,坏死性凋亡的特征是细胞肿胀、膜破裂,以及细胞质内容物的释放,这些过程会引发炎症反应和周围组织损伤。综述了坏死性凋亡的发现历程及其分子机制,重点探讨了TNF-α信号通路和受体相互作用蛋白激酶1(RIPK1)/受体相互作用蛋白激酶3(RIPK3)复合体的形成。同时,强调了活性氧在RIPK1介导的坏死性凋亡中的核心作用,并阐述了坏死性凋亡在宿主抗病毒防御中的关键角色。研究进展为坏死性凋亡的生物学功能研究提供参考,并为开发新的治疗策略提供理论基础。
Abstract:
Necrotic apoptosis is a regulated manner of cell death, usually triggered by the binding of death receptors and tumor necrosis factors or viral infection. Unlike cell apoptosis, necrotic apoptosis is characterized by cell swelling, membrane rupture, and the release of cytoplasmic contents, which may trigger an inflammatory response and surrounding tissue damage. The discovery process and molecular mechanism of necrotic apoptosis are reviewed, and the TNF-α signaling pathway and the formation of receptor interacting protein kinase 1(RIPK1)/receptor interacting protein kinase 3(RIPK3)complex are focused on discussing. At the same time, the central role of active oxygen in RIPK1-mediated necrotic apoptosis is emphasized and the key role of necrotic apoptosis in host antiviral defense is explained. This review provides a reference of the biological function of necrotic apoptosis and also a theoretical basis for the development of new therapeutic strategies.

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备注/Memo

备注/Memo:
收稿日期: 2025-01-02
通信作者: 佟雷(1980-),女,副教授,博士,主要从事病毒与肿瘤相互关系的研究。E-mail:leitong007@163.com。
基金项目: 福建省自然科学基金资助项目(2022J01311); 福建省泉州市高层次人才创新创业项目(2024QZC002YR)
更新日期/Last Update: 2025-05-20