[1]郑秀梅,杜鑫,柳培忠,等.虾青素复合纳米颗粒Pickering乳液的制备及评价[J].华侨大学学报(自然科学版),2024,45(6):756-765.[doi:10.11830/ISSN.1000-5013.202405019]
　ZHENG Xiumei,DU Xin,LIU Peizhong,et al.Preparation and Evaluation of Astaxanthin Composite Nanoparticles Pickering Emulsion[J].Journal of Huaqiao University(Natural Science),2024,45(6):756-765.[doi:10.11830/ISSN.1000-5013.202405019]
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虾青素复合纳米颗粒Pickering乳液的制备及评价()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第45卷
期数:
2024年第6期
页码:
756-765
栏目:
出版日期:
2024-11-15

文章信息/Info

Title:
Preparation and Evaluation of Astaxanthin Composite Nanoparticles Pickering Emulsion
文章编号:
1000-5013(2024)06-0756-10
作者:
郑秀梅1;  杜鑫1;  柳培忠1;  虞文熙1;  吴振2;  王立强1;  侯志勇1; 3
1. 华侨大学 生物医学学院, 福建泉州 362021;2. 厦门大学 药学院, 福建 厦门 361102;3. 解放军962医院, 黑龙江 哈尔滨 150080
Author(s):
ZHENG Xiumei1;  DU Xin1;  LIU Peizhong1;  YU Wenxi1;  WU Zhen2;  WANG Liqiang1;  HOU Zhiyong1; 3
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China; 3. 962 Hospital of Liberation Army, Harbin 150080, China
关键词:
虾青素;  Pickering乳液;  稳定性;  生物利用度
Keywords:
astaxanthin;  Pickering emulsion;  stability;  bioavailability
分类号:
R944.1
DOI:
10.11830/ISSN.1000-5013.202405019
文献标志码:
A
摘要:
利用固体颗粒(复合纳米颗粒)稳定油水界面的特性,制备玉米醇溶蛋白-虾青素纳米颗粒(Zein-AST NPs)和玉米醇溶蛋白-虾青素-阿拉伯胶复合纳米颗粒(Zein-AST-GA NPs),并比较它们的稳定性差异。以Zein-AST-GA NPs为稳定剂,使用含AST的玉米油制备Pickering乳液,研究乳液中AST的稳定性、体外释放率和大鼠体内药代动力学。实验结果显示:油相中含有AST的Pickering乳液(PE1)比油相中不含AST的Pickering乳液(PE2)具有更好的热稳定性和贮藏稳定性,且PE1具有较强的自由基清除能力,释放速率优于参比制剂和PE2,AST的释放符合菲克扩散规律;口服PE1后8 h达到最大AST血浆质量浓度(2.654 μg·mL-1),且相对生物利用度分别是市售虾青素微囊粉(AST-MCs)和PE2的1.703,1.481倍。
Abstract:
The property of solid particles(composite nanoparticles)to stabilize the oil-water interface was utilized to prepare corn zein-solubilized protein-astaxanthin nanoparticles(Zein-AST NPs)and corn zein-solubilized protein-astaxanthin-arabic gum composite nanoparticles(Zein-AST-GA NPs), and their stability differences were compared. Using Zein-AST-GA NPs as stabilizer, Pickering emulsion was prepared using corn oil containing AST. The stability, in vitro release rate, and in vivo pharmacokinetics in rats of AST in the emulsion were studied. The experimental results show that the Pickering emulsion containing AST(PE1)in the oil phase has better thermal and storage stability than the Pickering emulsion without AST in the oil phase(PE2), and PE1 has stronger free radical scavenging ability with a release rate superior to that of the reference formulation and PE2, and the release of AST is in accordance with Fick’s diffusion law. The maximum AST plasma mass concentration(2.654 μg·mL-1)is reached 8 hours after oral administration of PE1, and the relative bioavailability are 1.703 and 1.481 times higher than that of commercially available astaxanthin microcapsule powder(AST-MCs)and PE2, respectively.

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备注/Memo

备注/Memo:
收稿日期: 2024-05-01
通信作者: 侯志勇(1972-),男,副主任药师,主要从事创新药物的研究。E-mail:mpp5358@163.com。
基金项目: 国家重点研发计划项目(2016YFE0101700); 福建省高校产学合作重大项目(2019Y4007); 华侨大学研究生科研创新基金资助项目(18013071019)https://hdxb.hqu.edu.cn/
更新日期/Last Update: 2024-11-20