参考文献/References:
[1] LI Rongkun,WANG Yahui,ZHANG Xiaoxin,et al.Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis[J].Molecular Cancer,2019,18:18.DOI:10.1186/s12943-019-0948-8.
[2] ZHANG Yi,BI Jiayao,HUANG Jiayi,et al.Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications[J].International Journal of Nanomedicine,2020,15:6917-6934.DOI:10.2147/ijn.s264498.
[3] JOHNSTONE R M.The jeanne manery-fisher memorial lecture 1991: Maturation of reticulocytes: Formation of exosomes as a mechanism for shedding membrane proteins[J].Biochemistry and Cell Biology,1992,70(3/4):179-190.DOI:10.1139/o92-028.
[4] MAO Liang,LI Xue,GONG Shu,et al.Serum exosomes contain ECRG4 mRNA that suppr-esses tumor growth via inhibition of genes involved in inflammation, cell proliferation, and angiogenesis[J].Cancer Gene Therapy,2018,25(9/10):248-259.DOI:10.1038/s41417-018-0032-3.
[5] ZHAO Xiaoyin,WU Dongliang,MA Xudong,et al.Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake[J].Biomedicine & Pharmacotherapy,2020,128:110237.DOI:10.1016/j.biopha.2020.110237.
[6] MA Min,CHEN Shilin,LIU Zhuo,et al.MiRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer[J].Oncotargets and Therapy,2017,10:4161-4171.DOI:10.2147/ott.s143315.
[7] WANG Liyan,BO Xiaotong,YI Xiaoyuan,et al.Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway[J].Cell Death & Disease,2020,11(9):723.DOI:10.1038/s41419-020-02810-5.
[8] RONG Dawei,LU Chen,ZHANG B,et al.CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p[J].Molecular Cancer,2019,18(1):25.DOI:10.1186/s12943-019-0958-6.
[9] LIU Tong,ZHANG Xin,DU Lutao,et al.Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer[J].Molecular Cancer,2019,18(1):43.DOI:10.1186/s12943-019-0981-7.
[10] WANG Fengwei,CAO Chenhui,HAN Kai,et al.APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production[J].The Journal of Clinical Investigation,2019,129(2):727-743.DOI:10.1172/jci122478.
[11] SHANG Anquan,GU Chenzheng,WANG Weiwei,et al.Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis[J].Molecular Cancer,2020,19(1):117.DOI:10.1186/s12943-020-01235-0.
[12] QI Yongjian,ZHA Wangjian,ZHANG Wei.Exosomal miR-660-5p promotes tumor growth and metastasis in non-small cell lung cancer[J].Journal of BUON: Official Journal of the Balkan Union of Oncology,2019,24(2):599-607.
[13] YANG Xin,CHEN Yan,ZHOU You,et al.GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion[J].Oncogene,2021,40(25):4307-4323.DOI:10.1038/s41388-021-01837-y.
[14] ZHANG Kaiwen,LIU Dong,ZHAO Jianmei,et al.Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis[J].Cell Death & Disease,2021,12(6):554.DOI:10.1038/s41419-021-03845-y.
[15] PATEL G K,DUTTA S,SYED M M,et al.TBX2 drives neuroendocrine prostate cancer through exosome-mediated repression of miR-200c-3p[J].Cancers(Basel),2021,13(19):5020.DOI:10.3390/cancers13195020.
[16] WU Jianhong,SUN Kening,CHEN Zhihao,et al.Exosome-mediated miR-4792 transfer promotes bladder cancer cell proliferation via enhanced FOXC1/c-Myc signaling and warburg effect[J].Journal of Oncology,2022,2022:5680353.DOI:10.1155/2022/5680353.
[17] CHEN Xin,CHEN Rixin,WEI Wensu,et al.PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition[J].Clinical Cancer Research,2018,24(24):6319-6330.DOI:10.1158/1078-0432.ccr-18-1270.
[18] SONG Wenbin,CHEN Yule,ZHU Guodong,et al.Exosome-mediated miR-9-5p promotes proliferation and migration of renal cancer cells both in vitro and in vivo by targeting SOCS4[J].Biochemical and Biophysical Research Communications,2020,529(4):1216-1224.DOI:10.1016/j.bbrc.2020.06.114.
[19] WU Xiangguang,ZHOU Chenfei,ZHANG Yanmei,et al.Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma[J].Angiogenesis,2019,22(3):397-410.DOI:10.1007/s10456-019-09665-1.
[20] HE Liuqing,ZHU Wei,CHEN Quan,et al.Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis[J].Theranostics,2019,9(26):8206-8220.DOI:10.7150/thno.37455.
[21] GAO Xiaotong,WAN Zhuo,WEI Mengying,et al.Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320[J].Theranostics,2019,9(19):5642-5656.DOI:10.7150/thno.34813.
[22] HAN Mingli,HU Jianguo,LU Pengwei,et al.Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer[J].Cell Death & Disease,2020,11(1):43.DOI:10.1038/s41419-020-2250-5.
[23] GARIKIPATI V N,VERMA S K,CHENG Zhongjian,et al.Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis[J].Nature Communications,2019,10(1):4317.DOI:10.1038/s41467-019-11777-7.
[24] GUO Xin,Lü Xiaohui,RU Yi,et al.Circulating exosomal gastric cancer-associated long noncoding RNA1 as a biomarker for early detection and monitoring progression of gastric cancer: A multiphase study[J].JAMA Surgery,2020,155(7):572-579.DOI:10.1001/jamasurg.2020.1133.
[25] TANG Weiwei,FU Kai,SUN Handong,et al.CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer[J].Molecular Cancer,2018,17(1):137.DOI:10.1186/s12943-018-0888-8.
[26] YOON J,HAM I,KIM O,et al.Gastrokine 1 protein is a potential theragnostic target for gastric cancer[J].Gastric Cancer,2018,21(6):956-967.DOI:10.1007/s10120-018-0828-8.
[27] WANG Mei,QIU Rong,YU Shaorong,et al.Paclitaxel-resistant gastric cancer MGC-803 cells promote epithelial-to-mesenchymal transition and chemoresistance in paclitaxel sensitive cells via exosomal delivery of miR1555p[J].International Journal of Oncology,2019,54(1):326-338.DOI:10.3892/ijo.2018.4601.
[28] LI Jian,CHEN Yuxiang,GUO Xiong,et al.GPC1 exosome and its regulatory miRNAs are specific markers for the detection and target therapy of colorectal cancer[J].Journal of Cellular and Molecular Medicine,2017,21(5):838-847.DOI:10.1111/jcmm.12941.
[29] WANG Dong,WANG Xiaohui,SI Mahan,et al.Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages[J].Cancer Letters,2020,474:36-52.DOI:10.1016/j.canlet.2020.01.005.
[30] LIU Lin,MENG Tao,YANG Xinhui,et al.Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion[J].Cancer Biomark,2018,22(2):283-299.DOI:10.3233/cbm-171011.
[31] LI Yanyan,ZHANG Yuan,QIU Feng,et al.Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC[J].Electrophoresis,2011,32(15):1976-1983.DOI:10.1002/elps.201000598.
[32] ZANG Xueyan,GU Jianmei,ZHANG Jiayin,et al.Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression[J].Cell Death & Disease,2020,11(4):215.DOI:10.1038/s41419-020-2409-0.
[33] CLARK D J,FONDRIE W E,YANG A,et al.Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes[J].Journal of Proteomics,2016,133:161-169.DOI:10.1016/j.jprot.2015.12.023.
[34] WU Shaocong,LUO Min,KENNETH K,et al.Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer[J].Molecular Cancer,2021,20(1):17.DOI:10.1186/s12943-021-01307-9.
[35] WANG Yuhui,JI Jia,WANG Bicheng,et al.Tumo-derived exosomal long noncoding RNAs as promising diagnostic biomarkers for prostate cancer[J].Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology,2018,46:532-545.DOI:10.1159/000488620.
[36] FUJITA K,NONOMURA N.Urinary biomarkers of prostate cancer[J].International Journal of Urology(Official Journal of the Japanese Urological Association),2018,25(9):770-779.DOI:10.1111/iju.13734.
[37] YU Lijuan,SUI Bingdong,FAN Weixiao,et al.Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p[J].Journal of Extracellular Vesicles,2021,10(3):e12056.DOI:10.1002/jev2.12056.
[38] CHOU R,GORE J,BUCKLEY D,et al.Urinary biomarkers for diagnosis of bladder cancer: A systematic review and meta-analysis[J].Annals of Internal Medicine,2015,163(12):922-931.DOI:10.7326/m15-0997.
[39] ABBASTABAR M,SARFI M,GOLESTANI A,et al.Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer[J].Excli Journal,2020,19:301-310.DOI:10.17179/excli2019-1683.
[40] ZHANG Shujun,DU Lutao,WANG Lishui,et al.Evaluation of serum exosomal lncRNA-based biomarker panel for diagnosis and recurrence prediction of bladder cancer[J].Journal of Cellular and Molecular Medicine,2019,23(2):1396-1405.DOI:10.1111/jcmm.14042.
[41] GüLLü A,TINAY I,FILINTE D,et al.Urinary micro-RNA expressions and protein concentrations may differentiate bladder cancer patients from healthy controls[J].International Urology and Nephrology,2020,52(3):461-468.DOI:10.1007/s11255-019-02328-6.
[42] YAN Liang,LI Qi,SUN Ke,et al.MiR-4644 is upregulated in plasma exosomes of bladder cancer patients and promotes bladder cancer progression by targeting UBIAD1[J].American Journal of Translational Research,2020,12(10):6277-6289.
[43] PAN C,STEVIC I,MüLLER V,et al.Exosomal microRNAs as tumor markers in epithelial ovarian cancer[J].Molecular Oncology,2018,12(11):1935-1948.DOI:10.1002/1878-0261.12371.
[44] YOSHIDA K,YOKOI A,KATO T,et al.The clinical impact of intra-and extracellular miRNAs in ovarian cancer[J].Cancer Science,2020,111(10):3435-3444.DOI:10.1111/cas.14599.
[45] QIAN Mingyu,WANG Shaobo,GUO Xiaofan,et al.Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways[J].Oncogene,2020,39(2):428-442.DOI:10.1038/s41388-019-0996-y.
[46] RISHA Y,MINIC Z,GHOBADLOO S,et al.The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers[J].Scientific Reports,2020,10(1):13572.DOI:10.1038/s41598-020-70393-4.
[47] TANG Xiangjun,SUN Xuyong,HUANG Kuanming,et al.Therapeutic potential of CAR-T cell-derived exosomes: A cell-free modality for targeted cancer therapy[J].Oncotarget,2015,6(42):44179-44190.DOI:10.18632/oncotarget.6175.
[48] FEDERICI C,SHAHAJ E,CECCHETTI S,et al.Natural-killer-derived extracellular vesicles: Immune sensors and interactors[J].Frontiers in Immunology,2020,11:262.DOI:10.3389/fimmu.2020.00262.
[49] WU Shuwei,LI Lei,WANG Yan,et al.CTL-derived exosomes enhance the activation of CTLs stimulated by low-affinity peptides[J].Frontiers in Immunology,2019,10:1274.DOI:10.3389/fimmu.2019.01274.
[50] ZHANG Haifeng,XIE Yufeng,LI Wei,et al.CD4(+)T cell-released exosomes inhibit CD8(+)cytotoxic T-lymphocyte responses and antitumor immunity[J].Cellular & Molecular Immunology,2011,8(1):23-30.DOI:10.1038/cmi.2010.59.
[51] SHARMA A,JOHNSON A.Exosome DNA: Critical regulator of tumor immunity and a diagnostic biomarker[J].Journal of Cellular Physiology,2020,235(3):1921-1932.DOI:10.1002/jcp.29153.
[52] ZHU Liya,KALIMUTHU S,GANGADARAN P,et al.Exosomes derived from natural killer cells exert therapeutic effect in melanoma[J].Theranostics,2017,7(10):2732-2745.DOI:10.7150/thno.18752.
[53] HAO Dexun,LI Yanshuang,ZHAO Gaofeng,et al.Soluble fms-like tyrosine kinase-1-enriched exosomes suppress the growth of small cell lung cancer by inhibiting endothelial cell migration[J].Thoracic Cancer,2019,10(10):1962-1972.DOI:10.1111/1759-7714.13175.
[54] ZHOU Wenxi,ZHOU Yu,CHEN Xinli,et al.Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment[J].Biomaterials,2021,268:120546.DOI:10.1016/j.biomaterials.2020.120546.
[55] WANG Jie,CHEN Peng,DONG Yue,et al.Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy[J].Biomaterials,2021,276:121056.DOI:10.1016/j.biomaterials.2021.121056.
[56] LI Chi,DONNINGER H,EATON J,et al.Regulatory role of immune cell-derived extracellular vesicles in cancer: The message is in the envelope[J].Frontiers in Immunology,2020,11:1525.DOI:10.3389/fimmu.2020.01525.
[57] EMAM S E,ANDO H,ABU L,et al.A novel strategy to increase the yield of exosomes(extracellular vesicles)for an expansion of basic research[J].Biological & Pharmaceutical Bulletin,2018,41(5):733-742.DOI:10.1248/bpb.b17-00919.
[58] ZHANG Lin,YU Dihua.Exosomes in cancer development, metastasis, and immunity[J].Biochimica et Biophysica Acta-Reviews on Cancer,2019,1871(2):455-468.DOI:10.1016/j.bbcan.2019.04.00.