[1]杨镇伟,林琪,陈虹,等.以超高分子材料为载体研发新型固体缓释抑菌剂[J].华侨大学学报(自然科学版),2021,42(4):512-518.[doi:10.11830/ISSN.1000-5013.202012030]
　YANG Zhenwei,LIN Qi,CHEN Hong,et al.Research and Development of New Type of Solid Sustained-Release Bacteriostatic Agent With Ultra-High Molecular Material as Carrier[J].Journal of Huaqiao University(Natural Science),2021,42(4):512-518.[doi:10.11830/ISSN.1000-5013.202012030]
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以超高分子材料为载体研发新型固体缓释抑菌剂()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第42卷
期数:
2021年第4期
页码:
512-518
栏目:
出版日期:
2021-07-20

文章信息/Info

Title:
Research and Development of New Type of Solid Sustained-Release Bacteriostatic Agent With Ultra-High Molecular Material as Carrier
文章编号:
1000-5013(2021)04-0512-07
作者:
杨镇伟1;  林琪1;  陈虹2;  张蕊3;  王立强1
1. 华侨大学 医学院, 福建 泉州 362021;2. 苏州凯虹高分子科技有限公司, 江苏 苏州 215211;3. 深圳联创立达环境技术有限公司, 广东 深圳 518116
Author(s):
YANG Zhenwei1;  LIN Qi1;  CHEN Hong2; ZHANG Rui3;  WANG Liqiang1
1. School of Medicine, Huaqiao University, Quanzhou 362021, China; 2. Suzhou KaiHong Polymer Technology Limited Company, Suzhou 215211, China; 3. Shenzhen Lianchuanglida Environmental Technology Limited Company, Shenzhen 518116, China
关键词:
挥发性抑菌液;  超高分子材料;  固态;  缓释效果;  空气消毒
Keywords:
ultra-high molecular material;  volatile bacteriostatic solution;  solid state;  sustained-release effect;  air disinfection
分类号:
R187.1;TB324
DOI:
10.11830/ISSN.1000-5013.202012030
文献标志码:
A
摘要:
利用超高分子材料载体制备一种固体缓释抑菌剂,对其进行表征,检验其缓释及抑菌效果.将挥发性中西药复配抑菌液吸附于特定的超高分子材料载体,对超高分子材料的力学性能进行考察,观察其微观结构,并对固体缓释抑菌剂的缓释效果和抑菌效果进行评价.结果表明:超高分子材料的拉伸断裂应力为28.79 MPa,抗冲击强度为78.85 kJ·m-2,超高分子材料的孔隙率为69.17%,抑菌液吸附量为0.58 g·cm<sup>-3,抑菌液吸附率为141.38%;固体缓释抑菌剂的有效释放时长为10 d,对多种致病菌的平均杀灭率均高于99%;超高分子材料具有高强度的力学性能和较高的抑菌液吸附率;固体缓释抑菌剂释放速率稳定,在空气中分布均匀,缓释效果和抑菌效果良好.
Abstract:
A kind of solid sustained-release bacteriostatic agent was prepared by using ultra-high molecular material, and characterized to test its sustained-release and antibacterial effect. The volatile Chinese and Western medicine compound bacteriostatic solution was adsorbed on the specific ultra-high molecular materials carrier, the mechanical properties of the ultra-high molecular materials were investigated,their microstructure was observed,and the sustained-release effect and antibacterial effect of the solid sustained-release bacteriostatic agent were evaluated. The results showed that the tensile fracture stress of the ultra-high molecular materials was 28.79 MPa, the impact strength was 78.85 kJ·m-2, the porosity was 69.17%, and the adsorption capacity and adsorption rate of the bacteriostatic solution were 0.58 g·cm-3 and 141.38% respectively. The effective release time of the solid sustained-release bacteriostatic agent was 10 d, and the average killing rate of various pathogenic bacteria exceeded 99%. It indicates that the ultra-high molecular materials have high strength mechanical properties and high bacteriostatic solution adsorption rate. In addition, the release rate of solid sustained-release bacteriostatic agent is stable, the distribution in the air is uniform, and the sustained-release effect and and antibacterial effect are both good.

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备注/Memo

备注/Memo:
收稿日期: 2020-12-16
通信作者: 王立强(1970-),男,教授,博士,主要从事药剂学和创新药物的研究.E-mail:wlq1599@163.com.
基金项目: 国家重点研发计划项目(2016YFE0101700); 福建省高校产学合作重大项目(2019Y4007); 福建省泉州市2020年抗新冠应急项目(2020SY001)http://www.hdxb.hqu.edu.cn
更新日期/Last Update: 2021-07-20