[1]王国权,庞素秋,刘蒲,等.楮实子油对大鼠血脂和脂肪组织的影响[J].华侨大学学报(自然科学版),2017,38(5):682-686.[doi:10.11830/ISSN.1000-5013.201705035]
　WANG Guoquan,PANG Suqiu,LIU Pu,et al.Effects of Fructus Broussonetiae Oil on Blood Lipids and Adipose Tissue in Rats[J].Journal of Huaqiao University(Natural Science),2017,38(5):682-686.[doi:10.11830/ISSN.1000-5013.201705035]
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楮实子油对大鼠血脂和脂肪组织的影响()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第38卷
期数:
2017年第5期
页码:
682-686
栏目:
出版日期:
2017-09-20

文章信息/Info

Title:
Effects of Fructus Broussonetiae Oil on Blood Lipids and Adipose Tissue in Rats
文章编号:
1000-5013(2017)05-0682-05
作者:
王国权1; 2;  庞素秋3;  刘蒲1; 2;  李永4;  林俊生1; 2;  刁勇1; 2
1. 华侨大学 生物医学学院, 福建 泉州 362021;2. 华侨大学 医学院, 福建 泉州 362021;3. 中国人民解放军第180医院 临床药学科, 福建 泉州 362000;4. 华侨大学 化工学院, 福建 厦门 361021
Author(s):
WANG Guoquan1; 2;  PANG Suqiu3;  LIU Pu1; 2;  LI Yong4;  LIN Junsheng1; 2;  DIAO Yong1; 2
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. School of Medicine, Huaqiao University, Quanzhou 362021, China; 3. Department of Clinical Pharmacy, The 180th Hospital of People’s Liberation Army, Quanzhou 362000, China; 4.
关键词:
楮实子油;  多不饱和脂肪酸;  δ-生育酚;  血脂;  脂肪组织;  大鼠
Keywords:
fructus broussonetiae oil;  polyunsaturated fatty acids;  δ-tocopherol;  plasma lipids;  adipose tissue;  rat
分类号:
R285.5
DOI:
10.11830/ISSN.1000-5013.201705035
文献标志码:
A
摘要:
探讨楮实子油(FBO)的脂肪酸的化学组成及其对大鼠血脂和脂肪组织的影响.首先,用气相色谱与质谱联用(GC-MS)法对FBO脂肪酸化学成分进行分析测定;然后,给48只雄性Wistar大鼠饲喂含胆固醇和FBO的饲料28 d,以空白对照和辛伐他汀分散片阳性药对照比较FBO对大鼠血脂指标和脂肪组织的影响.结果表明:GC-MS法测定出FBO中的11个化合物,主要成分为亚油酸(67.03%)、棕榈酸(30.53%)、亚麻酸(1.45%)和δ-生育酚;FBO可显著降低高脂模型大鼠肝脏及脂肪组织的质量,降低甘油三酯、总胆固醇和低密度脂蛋白胆固醇(LDL-C)浓度,升高高密度脂蛋白胆固醇(HDL-C)的浓度.此外,FBO中68%以上为多不饱和脂肪酸,并含有少量强抗氧化剂δ-生育酚(0.54%),二者可能是影响高脂模型大鼠有调节血脂和抑制皮下脂肪组织聚集作用的主要成分.
Abstract:
The chemical compositions of fructus broussonetiae oil(FBO)and the effects of dietary FBO on the plasma lipids and adipose tissue were investigated in this study. The chemical composition of FBO fatty acid was determined by gas chromatography and mass spectrometry(GC-MS). Then the effects of FBO on lipid indexes and adipose tissue of 48 male Wistar rats who were fed with diet containing FBO and cholesterol for 28 days were compared using blank control and simvastatin dispersible tablets as positive control. The results showed that eleven compounds were identified from FBO, with the main ingredients of linoleic acid(67.03%), hexadecanoic acid(30.53%), linolenic acid(1.45%), and delta-tocopherol. The FBO could significantly decrease the adipose tissue weight, and the concentrations of triacylglycerol, total cholesterol and low-density li--收稿日期:2017-05-18通信作者:庞素秋(1972-),女,副主任药师,博士,主要从事天然药物研发的研究.E-mail:1074730795@qq.com.基金项目:福建省泉州市科技计划项目(200712Z)http://www.hdxb.hqu.edu.cnpoprotein cholesterol(LDL-C), whereas increase the concentration of high-density lipoprotein cholesterol(HDL-C). In addition, more than 68% of FBO were multiple unsaturated fatty acids, and contained a small number of powerful antioxidant delta- tocopherol(0.54%), both of which might be the main ingredients which could regulate blood lipid and inhibit the aggregation in subcutaneous adipose tissue of the high fat model rats.

参考文献/References:

[1] 陶弘景.名医别录[M].北京:人民卫生出版社,1986:414.
[2] 张尊祥,戴新民,杨然,等.楮实对老年痴呆血液 LPO、SOD和脂蛋白的影响[J].解放军药学学报,1999,15(4):5-7.DOI:10.3969/j.issn.1008-9926.1999.04.002.
[3] PANG Suqiu,WANG Guoquan,HUANG Baokang,et al.Isoquinoline alkaloids from Broussonetia papyrifera fruits[J].Chemistry of Natural Compounds,2007,43(1):100-102.DOI:10.1007/s10600-007-0042-0.
[4] PANG Suqiu,WANG Guoquan,LIN Junsheng,et al.Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits[J].Pharmaceutical Biology,2014,52(10):1315-1319.DOI:10.3109/13880209.2014.891139.
[5] LI Yinghong,HU Li,WU Zhengzhi,et al.Fructus broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer’s disease models[J]. Neural Regeneration Research,2011,6(30):2325-2331.DOI:10.3969/j.issn.1673-5374.2011.30.001.
[6] 袁晓,袁萍.超临界二氧化碳萃取楮实子油化学成分的研究[J].中草药,2005,36(8):1136-1138.DOI:10.3321/j.issn:0253-2670.2005.08.006.
[7] ZHAO Hongfang,HUANG Linzhang,QIN Luping,et al.Antioxidative and anti-inflammatory properties of Chushizi oil from fructus broussonetiae[J].Journal of Medicinal Plants Research,2011,5(28):6407-6412.DOI:10.5897/JMPR11.447.
[8] 中华人民共和国药典委员会.中华人民共和国药典: 一部[M].北京:中国医药科技出版社,2010:315.
[9] 谭亚芳.紫苏子油中脂肪酸组成的分析[J].中国药学杂志,1998,33(7):400-402.DOI:10.3321/j.issn:1001-2494.1998.07.005.
[10] 徐伟东,陈钢,李丽珍.气相色谱法测定大豆油中脂肪酸组分的方法改进[J].中国药学杂志,2003,38(5):379-381.DOI:10.3321/j.issn:1001-2494.2003.05.022.
[11] 徐叔云,卞如廉,陈修.药理实验方法学[M].北京:人民卫生出版社,2002:203.
[12] 蔡双莲,李敏.多不饱和脂肪酸的研究进展[J].生命科学研究,2003,7(4):289-292.DOI:10.3969/j.issn.1007-7847.2003.04.002.
[13] 赵华,王康宁.多不饱和脂肪酸对动物体脂沉积及其基因表达的影响[J].动物营养学报,2004,16(1):1-5.DOI:10.3969/j.issn.1006-267X.2004.01.001.
[14] 贾曼雪,薛楠,曹子鹏,等.多不饱和脂肪酸不同配比对大鼠血脂影响[J].中国公共卫生,2009,25(3):348-350.DOI:10.3321/j.issn:1001-0580.2009.03.026.
[15] 陈建斌,饶邦复.抗氧化剂的研究进展[J].心血管病学进展,1995,16(3):153-155.
[16] 杨栓平,常学锋,王志平,等.核桃油和核桃油复合维生素E对大鼠血浆脂质的影响[J].营养学报,2001,23(3):267-270.DOI:10.3321/j.issn:0512-7955.2001.03.020.

备注/Memo

备注/Memo:
收稿日期: 2017-05-18
通信作者: 庞素秋(1972-),女,副主任药师,博士,主要从事天然药物研发的研究.E-mail:1074730795@qq.com.
基金项目: 福建省泉州市科技计划项目(200712Z)http://www.hdxb.hqu.edu.cn
更新日期/Last Update: 2017-09-20