[1]王立强,卢迅,应侠,等.DTPA胃漂浮囊心缓释片制备与体外释放性能[J].华侨大学学报(自然科学版),2017,38(2):175-179.[doi:10.11830/ISSN.1000-5013.201702008]
　WANG Liqiang,LU Xun,YING Xia,et al.Preparation and In Vitro Release of DTPA Intragastric Floating Sustained-Release and Capsule-Heart Tablets[J].Journal of Huaqiao University(Natural Science),2017,38(2):175-179.[doi:10.11830/ISSN.1000-5013.201702008]
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DTPA胃漂浮囊心缓释片制备与体外释放性能()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第38卷
期数:
2017年第2期
页码:
175-179
栏目:
出版日期:
2017-03-20

文章信息/Info

Title:
Preparation and In Vitro Release of DTPA Intragastric Floating Sustained-Release and Capsule-Heart Tablets
文章编号:
1000-5013(2017)02-0175-05
作者:
王立强1;  卢迅1;  应侠1;  陈锐2
1. 华侨大学 生物医学学院, 福建 泉州 362021;2. 广州优米健医药科技有限公司, 广东 广州 510060
Author(s):
WANG Liqiang1;  LU Xun1;  YING Xia1;  CHEN Rui2
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. Guangzhou Youmijian Pharmaceutical Technology Company Limited, Guangzhou 510060, China
关键词:
二乙基三胺五乙酸;  胃漂浮囊心缓释片;  漂浮性能;  释药机理
Keywords:
diethylene triamine pentaacetic acid;  intragastric floating sustained-release and capsule-heart tablets;  floating characteristics;  release mechanism
分类号:
R944
DOI:
10.11830/ISSN.1000-5013.201702008
文献标志码:
A
摘要:
采用粉末直接压片法制备二乙基三胺五乙酸(DTPA)胃漂浮囊心缓释片,并对其进行体外漂浮性能、释放性能和释药机理研究.结果表明:DTPA胃漂浮囊心缓释片在人工胃液中可以立即起漂,持续漂浮时间长达24 h,其释药过程用Korsmeyer-Peppas(Tlag)模型拟合的拟合度最好;同时,应用Harland方程进行验证,证明该制剂的释药过程主要为扩散和骨架溶蚀共同作用.通过该法制备的胃漂浮囊心缓释片具有起漂时间短、持续漂浮时间长、缓释效果好,漂浮性能不受制剂辅料和制备工艺的影响等优点.
Abstract:
Diethylene triamine pentaacetic acid(DTPA)intragastric floating sustained-release and capsule-heart tablets were prepared by pressing the powder directly, and the in vitro floatation, release characteristics and release mechanism were studied. Results indicated that DTPA intragastric floating sustained-release and capsule-heart tablets could float immediately in the simulated gastric fluid, floating up to 24 hours continuously, and the in vitro drug release with Korsmeyer-Peppas(Tlag)model fitting was the best. At the same time, it was proved that the drug release was controlled by diffusion and matrix erosion together using Harland equation for validation. In conclusion, intragastric floating sustained-release and capsule-heart tablets have the advantages of short floating lag time, long floating duration and good sustained-release effect. In addition, the floating characteristics were not affected by the excipients and the preparation technologies.

参考文献/References:

[1] 陈伟茂.药物制剂新技术概述及其药剂制作中的实例研究[J].中国当代医药,2011,18(7):6-15.
[2] SARIC M M,BLANUSA M,JURESA D,et al.Combined early treatment with chelating agents DMSA and CaDTPA in acute oral cadmium exposure[J].Basic Clin Pharmacol Toxicol,2004,94(3):119-123.
[3] 陆志城.喷替酸钙三钠和喷替酸锌三钠注射液[N].医药经济报,2005,8(19):A07.
[4] LAINE P,MATILAINEN R.Simultaneous determination of DTPA, EDTA, and NTA by UV-visible spectrometry and HPLC[J].Analytical and Bioanalytical Chemistry,2005,382(7):1601-1609.
[5] 丁友超,李建军,吴丽娜,等.Fe3+络合-离子对液相色谱-串联质谱测定纺织品中乙二胺四乙酸盐和二乙烯三胺五乙酸盐[J].分析试验室,2012,31(8):27-32.
[6] 陈红红,罗梅初,孙梅贞,等.反相高效液相色谱法测定二乙烯三胺五醋酸注射液的含量[J].中国现代应用药学,1998,15(6):40-42.
[7] CAGNASSO C E,LOPEZ L B,RODRIGUEZ V G,et al.Development and validation of a method for the determination of EDTA in non-alcoholic drinks by HPLC[J].Journal of Food Composition and Analysis,2007,20(3/4):248-251.
[8] 国家药典委员会.中华人民共和国药典: 二部[S].2010年版.北京:中国医药科技出版社,2010:附录86-87.
[9] ZHANG Yong,HUO Meirong,ZHOU Jianping,et al.DDSolver: An add-in program for modeling and comparison of drug dissolution profiles[J].AAPS J,2010,12(3):263-271.
[10] COSTA P,SOUSA L J.Modeling and comparison of dissolution profiles[J].Eur J Pharm Sci,2001,13(2):123-133.
[11] TAHARA K,YAMAMOTO K,NISHIHATA O.Overall mechanism behind matrix sustained release tablets prepared with hydroxyprpyl methylcellulose 2910[J].J Controlled Release,1995,35(1):59-66.

备注/Memo

备注/Memo:
收稿日期: 2016-10-25
通信作者: 王立强(1970-),男,教授,博士,主要从事药剂学和创新药物研发的研究.E-mail:wlq1599@163.com.
基金项目: 福建省自然科学基金资助项目(2015J01342)
更新日期/Last Update: 2017-03-20