[1]彭皓,雷飞.医药洁净室的计算流体动力学模拟及实测对比[J].华侨大学学报(自然科学版),2015,36(1):49-54.[doi:10.11830/ISSN.1000-5013.2015.01.0049]
　PENG Hao,LEI Fei.Computational Fluid Dynamics Simulation and Measured Contrast Research of Pharmaceutical Clean Room[J].Journal of Huaqiao University(Natural Science),2015,36(1):49-54.[doi:10.11830/ISSN.1000-5013.2015.01.0049]
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医药洁净室的计算流体动力学模拟及实测对比()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第36卷
期数:
2015年第1期
页码:
49-54
栏目:
出版日期:
2015-01-20

文章信息/Info

Title:
Computational Fluid Dynamics Simulation and Measured Contrast Research of Pharmaceutical Clean Room
文章编号:
1000-5013(2015)01-0049-06
作者:
彭皓1;  雷飞2
1. 中国医药集团联合工程有限公司, 湖北 武汉 430077;2. 华中科技大学 环境科学与工程学院, 湖北 武汉 430077
Author(s):
PENG Hao1;  LEI Fei2
1. China National Pharmaceutical Group Corporation, Wuhan 430074, China; 2. School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
关键词:
洁净室;  计算流体动力学;  污染物;  散发位置;  洁净度;  发尘量
Keywords:
clean room;  computational fluid dynamics;  pollutant emission;  position;  cleanliness;  dust content
分类号:
TU834.844;O35
DOI:
10.11830/ISSN.1000-5013.2015.01.0049
文献标志码:
A
摘要:
采用计算流体动力学(CFD)模拟,研究3个医药洁净室的气流流型及颗粒物浓度.采用标准k-ε双方程模型,通过模拟颗粒物在洁净室的分布,分析合理的污染物散发位置及散发比例.对比参考发尘量下的结果与实测数据的差异,根据实测数据确定污染散发量,通过试验不同的单位容积发尘量,计算对应的洁净度,得到与实测数据吻合最好的单位容积发尘量.在单位容积发尘量为1 000 pc·(m3·min)-1计算条件下,各房间的模拟结果与实测数据数值比较吻合,且经CFD预测的3个房间的洁净度变化趋势与实测一致.
Abstract:
In this work, the air flow patterns and particle concentrations of three pharmaceutical clean rooms were studied using computational fluid dynamics(CFD)simulation. A standard k-ε double-equation model was used to simulate the distribution of particles in the clean room and analyze the rational pollutant dissemination position and distribution ratio. By comparing the differences between the results of the referenced dust content and the measured data, the pollution emissions were determined according to the measured data. And the corresponding cleanliness was calculated by changing the dust content per unit volume(DCPUV)to get the best DCPUV value which was in accordance with the experimental data. When the DCPUV reached 1 000 pc·(m3·min)-1, the numerical simulation results and experimental data of each room fit well, and the cleanliness of three rooms is consistent with the observed trends by the CFD predictions.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2015-01-15
通信作者: 彭皓(1970-),男,高级工程师,主要从事医药洁净厂房无菌生产区环境控制的研究.E-mail:pmt1322@tom.com.
基金项目: 中国医药集团新产品开发基金资助项目(2011GC02)
更新日期/Last Update: 2015-01-20