[1]刘玮炜,李曲祥,程峰昌,等.含D-乙酰氨基葡萄糖和哌嗪的脲类化合物的合成及表征[J].华侨大学学报(自然科学版),2014,35(6):685-688.[doi:10.11830/ISSN.1000-5013.2014.06.0685]
 LIU Wei-wei,LI Qu-xiang,CHENG Feng-chang,et al.Synthesis and Characterization of Urea Derivatives Containing D-Acetylglucosamine and Piperazine[J].Journal of Huaqiao University(Natural Science),2014,35(6):685-688.[doi:10.11830/ISSN.1000-5013.2014.06.0685]
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含D-乙酰氨基葡萄糖和哌嗪的脲类化合物的合成及表征()
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《华侨大学学报(自然科学版)》[ISSN:1000-5013/CN:35-1079/N]

卷:
第35卷
期数:
2014年第6期
页码:
685-688
栏目:
出版日期:
2014-11-20

文章信息/Info

Title:
Synthesis and Characterization of Urea Derivatives Containing D-Acetylglucosamine and Piperazine
文章编号:
1000-5013(2014)06-0685-04
作者:
刘玮炜123 李曲祥2 程峰昌2 张强2 霍云峰1
1. 淮海工学院 化学工程学院, 江苏 连云港 222005;2. 中国矿业大学 化工学院, 江苏 徐州 221116;3. 江苏省海洋资源开发研究院, 江苏 连云港 222005
Author(s):
LIU Wei-wei123 LI Qu-xiang2 CHENG Feng-chang2 ZHANG Qiang2 HUO Yun-feng1
1. Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China; 2. Department of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116, China; 3. Jiangsu Institute of Marine Resources, Lianyungan
关键词:
脲类化合物 D-氨基葡萄糖 哌嗪衍生物 一锅法
Keywords:
uera compounds D-glucosamine piperazine derivatives one pot
分类号:
O629.11
DOI:
10.11830/ISSN.1000-5013.2014.06.0685
文献标志码:
A
摘要:
以D-氨基葡萄糖盐酸盐为起始原料,经过羟基的乙酰化保护,得到2-氨基-1,3,4,6-四-O-乙酰基-2-脱氧-β-D-吡喃糖盐酸盐;然后在三乙胺存在下,与三光气、哌嗪衍生物“一锅法”反应,合成4种具有代表性的糖基哌嗪物质.产物结构均经FT-IR,1H NMR和HRMS(ESI)确认.
Abstract:
2-Amino-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose was synthesized by acetylation of hydroxy groups with D-glucosa as starting material. Under the catalysis of triethyla, four representative glycosylpiperazines were obtained via one-pot reaction of acetylglucosa, triphosgene and piperazine derivatives. The products were confirmed by FT-IR, 1H NMR and HRMS(ESI).

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2014-05-16
通信作者: 刘玮炜(1965-),女,教授,主要从事有机合成等方面的研究.E-mail:liuww2007ly@aliyun.com.
基金项目: 江苏省高校自然科学研究重大项目(10KJA170003); 江苏省高校科研成果产业化推进项目(JHB2012-60); 江苏省连云港市科技攻关及江苏高校优势学科建设工程基金资助项目(CG1105)
更新日期/Last Update: 2014-11-20