[1]车玉彩,庄其仁,智佳军.光学生物芯片梯形聚合物光栅的优化设计[J].华侨大学学报(自然科学版),2013,34(4):380-384.[doi:10.11830/ISSN.1000-5013.2013.04.0380]
　CHE Yu-cai,ZHUANG Qi-ren,ZHI Jia-jun.Optimal Design of the Trapezoidal Polymer Grating for Optical Biochip[J].Journal of Huaqiao University(Natural Science),2013,34(4):380-384.[doi:10.11830/ISSN.1000-5013.2013.04.0380]
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光学生物芯片梯形聚合物光栅的优化设计()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第34卷
期数:
2013年第4期
页码:
380-384
栏目:
出版日期:
2013-07-20

文章信息/Info

Title:
Optimal Design of the Trapezoidal Polymer Grating for Optical Biochip
文章编号:
1000-5013(2013)04-0380-05
作者:
车玉彩;  庄其仁;  智佳军
华侨大学 信息科学与工程学院, 福建 厦门 361021
Author(s):
CHE Yu-cai;  ZHUANG Qi-ren;  ZHI Jia-jun
College of Information Science and Engineering, Huaqiao University, Xiamen 361021, China
关键词:
生物芯片;  梯形光栅;  占空比;  衍射光强比;  聚合物
Keywords:
bio-chips;  trapezoid grating;  occupy ratio;  diffraction intensity ratio;  polymer
分类号:
O437.4
DOI:
10.11830/ISSN.1000-5013.2013.04.0380
文献标志码:
A
摘要:
利用光栅标量衍射理论的数值求解法,研究一种可以包埋蛋白质分子的梯形聚合物光栅,用于制作光学生物芯片.通过分析二元光栅结构参数和折射率的变化对±1级和0级衍射光强比的影响,获得优化的光栅结构参数:光栅凹槽深度h0为0.6 μm;光栅周期d为4 μm; 工作波长λ为632.8 nm;聚合物折射率n0为1.522;两斜边角度α1为31°,α2为90°;占空比v为0.7;埋入核酸适体厚度h为0.05 μm.
Abstract:
The trapezoid polymer gratings used for optical biochip, in which protein molecules can be embedded, are discussed by using numerical method of the grating scalar diffraction theory. Analysis of the influence of diffraction intensity ratio, the 1st-order(plus or minus)and the zero-order, due to changes in dual refractive index and grating structure parameters, the optimized structure parameters of grating occurred at grating groove of depth 0.6 μm, grating constant 4 μm, light of wavelength 632.8 μm, polymer with a refractive index of 1.552, two bevel angles α1=31° and α2=90°, duty-cycle is 0.7, and the embedded aptamers’s thickness h=0.05 μm.

参考文献/References:

[1] MILLER A E,HOLLARS C W,LANE S M,et al.Fluorescence cross-correlation spectroscopy as a universal method for protein detection with low false positives[J].Analytical Chemistry,2009,81(14):5614-5622.
[2] HAN X X,JIA H Y,WANG Y F,et al.Analyticaltechnique for label-free multi-protein detection based on western blot and surface-enhanced raman scattering[J].Analytica Chemistry,2008,80(8):2799-2804.
[3] SHAN Gui-ye,WANG Shuang,FEI Xiao-fang,et al.Heterostructured ZnO/Au nanoparticles-based resonant raman scattering for protein detection[J].Journal of Physical Chemistry B,2009,113(5):1468-1472.
[4] CHIEN J H,CHEN P H,KUO L S,et al.Protein detection using a radio frequency biosensor with amplified gold nanoparticles[J].Applied Physics Letters,2007,91(14):143901-143904.
[5] KIM Y H,KIM J P,HAN S J,et al.Aptamer biosensor for lable-free detection of human immunoglobulin E based on surface plasmon resonance[J].Sensors and Actuators B: Chemical,2009,139(2):471-475.
[6] CHENG A K H,SEN D,YU H Z.Design and testing of aptamer-based electrochemical biosensors for proteins and small molecules[J].Bioelectrochemistry,2009,77(1):1-12.
[7] 徒永华,程圭芳,林莉,等.基于核酸适配体的新型荧光纳米生物传感器用于凝血酶的测定[J].高等学校化学学报,2006,27(12):2266 -2270.
[8] GIRIDHARAN G,JAY R U,DOUGLAS F H.DNA aptamer-based bioanalysis of IgE by fluorescence anisotropy[J].Analytical Chemistry,2005,77(7):1963-1970.
[9] LIAO W,ALBA N A,RANDALL B A,et al.Conducting polymer-based impedimetric aptamer biosensor for in situ detection[J].Analytical and Bioanalytical-Chemistry,2008,392(5):861-864.
[10] 刘荣祁,陈建荣,林宝卿,等.浮雕矩形光栅刻槽深度的衍射测量方法[J].应用激光,2009,29(3):252-255.
[11] 江天府,文军,蒋昌云.位相光栅的矢量和标量衍射理论的分析比较[J].广西师范大学学报:自然科学版,2001,19(3):15-18.
[12] BORN M,WOLF E.Principles of optics: Electromagnetic theory of propagation,interference and diffraction of light[M].Oxford: New York Pergamon Press,1999:425-430.
[13] 张海涛,巩马理,赵达尊,等.高密度光盘存储中的梯形光栅设计和误差分析[J].光学学报,2002,22(1):92-98.
[14] 于百英,庄其仁,阮思旭.采用模压技术的聚合物矩形光栅制作[J].华侨大学学报:自然科学版,2007,28(2):151-154.

备注/Memo

备注/Memo:
收稿日期: 2012-05-19
通信作者: 庄其仁(1960-),男,教授,主要从事光电子应用技术的研究.E-mail:qrzhuang@hqu.edu.cn.
基金项目: 福建省自然科学基金计划资助项目(2011J01353)
更新日期/Last Update: 2013-07-20