[1]于瑞莲,胡恭任.苯胺类化合物对发光菌的毒性及定量构效[J].华侨大学学报(自然科学版),2005,26(2):195-198.[doi:10.3969/j.issn.1000-5013.2005.02.022]
　Yu Ruilian,Hu Gongren.Toxicity of Anilines to Photobacterium phosphoreum and the Quantitative Structure-Activity Relationship[J].Journal of Huaqiao University(Natural Science),2005,26(2):195-198.[doi:10.3969/j.issn.1000-5013.2005.02.022]
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苯胺类化合物对发光菌的毒性及定量构效()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第26卷
期数:
2005年第2期
页码:
195-198
栏目:
出版日期:
2005-04-20

文章信息/Info

Title:
Toxicity of Anilines to Photobacterium phosphoreum and the Quantitative Structure-Activity Relationship
文章编号:
1000-5013(2005)02-0195-04
作者:
于瑞莲; 胡恭任
华侨大学材料科学与工程学院; 华侨大学材料科学与工程学院 福建泉州362021; 福建泉州362021
Author(s):
Yu Ruilian;  Hu Gongren
College of Material Science and Engineering, Huaqiao University, 362021, Quanzhou, China
关键词:
苯胺类化合物;  发光菌;  15 min-EC50;  QSAR;  毒性机制
Keywords:
anilines;  Photobacterium phosphoreum;  15 min-EC50;  quantitative structure-activity relationship;  mechanism of toxicity
分类号:
X172
DOI:
10.3969/j.issn.1000-5013.2005.02.022
文献标志码:
A
摘要:
测定13种苯胺类化合物,研究在pH值为5.0,7.0,9.0时对发光菌的急性毒性(15minEC50).应用两种理化参数logP和pKa,对毒性数据进行定量构效关系(QSARs)研究,探讨苯胺类化合物的毒性机制.结果表明,苯胺类化合物对发光菌的毒性随pH值的升高而增大,这与不同pH值下苯胺类化合物的电离程度有关.在相同pH值下,苯胺类化合物的毒性随取代基团的种类、个数及取代位置而不同.苯胺类化合物属于极性麻醉化合物,其对发光菌的毒性以亲电性为主,毒性可用logP和pKa来联合描述.
Abstract:
The acute toxicity of 13 anilines to Photobacterium phosphoreum at different pH(pH 5.0, 7.0 and 9.0) are determined by taking 15 min-EC_~50 as indicator which means the concentration value causing a 50% inhibion of bio-luminescence after 15 minutes. The quantitative structure-activity relationship is studied by applying two physico-chemical parameters logP and pK_a. The mechanism of toxicity of anilines to Photobacterium phosphoreum is also investigated. The results show that the toxicity of anilines to Photobacterium phosphoreum increases with the rise of pH. This phenomenon is relevant to the ionization degree of anilines at different pH. At the same pH, the toxicity of anilines is differing with the variety, the number and the substitution position of substituent group. Anilines belong to polar narcotic compounds. Its toxicity to Photobacterium phosphoreum is mainly electrophilic. The toxicity can be described by logP in combination with pK_a.

参考文献/References:

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备注/Memo

备注/Memo:
华侨大学科研基金资助项目(02HZR01)
更新日期/Last Update: 2014-03-23