[1]于瑞莲,赵元慧,胡恭任.酚类对大型蚤的急性毒性及QSAR研究[J].华侨大学学报(自然科学版),2003,24(1):44-47.[doi:10.3969/j.issn.1000-5013.2003.01.008]
　Yu Ruilian,Zhao Yuanhui,Hu Gongren.Acute Toxicity of Phenol Chemicals to Daphnia Magna at Different pH Values and the QSAR Study[J].Journal of Huaqiao University(Natural Science),2003,24(1):44-47.[doi:10.3969/j.issn.1000-5013.2003.01.008]
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酚类对大型蚤的急性毒性及QSAR研究()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第24卷
期数:
2003年第1期
页码:
44-47
栏目:
出版日期:
2003-01-20

文章信息/Info

Title:
Acute Toxicity of Phenol Chemicals to Daphnia Magna at Different pH Values and the QSAR Study
文章编号:
1000-5013(2003)01-0044-04
作者:
于瑞莲; 赵元慧; 胡恭任
华侨大学材料科学与工程学院; 东北师范大学环境科学系; 华侨大学材料科学与工程学院 福建泉州362011; 吉林长春130024; 福建泉州362011
Author(s):
Yu Ruilian1;  Zhao Yuanhui2;  Hu Gongren1
1.College of Mater. Sci. & Eng., Huaqiao Univ., 362011, Quanzhou, China; 2.Dept. of Environ. Sci., Northeast Normal Univ., 130024, Changchun, China
关键词:
苯酚类化合物;  大型蚤;  IC50;  pH值;  QSAR;  毒性机制
Keywords:
phenol chemicals;  Daphnia Magna;  IC50;  pH value;  QSAR;  mechanism of toxicity
分类号:
X839.2
DOI:
10.3969/j.issn.1000-5013.2003.01.008
文献标志码:
A
摘要:
在不同 p H值下,测定 11种苯酚类化合物对大型蚤 (Daphnia Magna) 2 4 h的半数活动抑制浓度 IC50 .应用 3种理化参数 log P,TSA和 p Ka,对毒性数据进行定量构效相关 (QSAR)研究 .在此基础上,初步探讨苯酚类化合物的毒性机制 .
Abstract:
The toxicity of 11 kinds of phenol chemicals to Daphnia Magna at pH 6.0, 7.8 and 9.0 are reflected by measuring the concentration for inhibiting the activities of half of them during 24 hours, or IC 50 for short. The study of quantitative structure-activity relationships, or QSAR for short, is made on toxicity data by applying 3 kinds of physicochemical parameters log P, TSA and pKa. On this basis, an initial inquiry is made into the mechanism of toxicity of phenol chemicals.

参考文献/References:

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备注/Memo

备注/Memo:
华侨大学科研基金资助项目(02HZR01)
更新日期/Last Update: 2014-03-23