[1]孙向英,刘斌,徐金瑞.pH及电位敏感的聚苯胺膜用于药物释放[J].华侨大学学报(自然科学版),2000,21(1):24-27.[doi:10.3969/j.issn.1000-5013.2000.01.006]
　Sun Xiangying,Liu Bin,Xu Jinrui.PH and Potential Sensitive Film of Polyaniline for the Use of Drug Release[J].Journal of Huaqiao University(Natural Science),2000,21(1):24-27.[doi:10.3969/j.issn.1000-5013.2000.01.006]
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pH及电位敏感的聚苯胺膜用于药物释放()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第21卷
期数:
2000年第1期
页码:
24-27
栏目:
出版日期:
2000-01-20

文章信息/Info

Title:
PH and Potential Sensitive Film of Polyaniline for the Use of Drug Release
文章编号:
1000-5013(2000)01-0024-04
作者:
孙向英; 刘斌; 徐金瑞
华侨大学化工学院, 泉州362011
Author(s):
Sun Xiangying;  Liu Bin;  Xu Jinrui
College of Chem. Eng., Huaqiao Univ., 362011, Quanzhou
关键词:
电化学控制;  聚苯胺膜;  pH;  半胱氨酸
Keywords:
electrochemical control;  film of polyaniline;  pH;  cysteine
分类号:
TQ460
DOI:
10.3969/j.issn.1000-5013.2000.01.006
摘要:
利用修饰电极及电化学控制方式对药物进行定量的负载与释放是一项具有开拓性的科学研究 .概述了用电化学聚合方法制备具有 p H响应的聚苯胺膜,通过电位来控制药物半胱氨酸的负载与释放 .结果表明,其释放速度和释放量由还原电位及释放时间控制,最佳释放电位为 - 0 .7V,最佳释放时间为 12 min,而且该聚合膜可循环负载释放,释放前后膜的 p H响应特性不发生改变 .这对于一些病症的诊断及防治具有一定的指导作用
Abstract:
It is a poineering work to use modified electrodes and electrochemical control for quantitatively loading and releasing drug. A brief account is given here of the preparation pH responsive film of polyaniline by electrochemical polymerization and of the potential control of film load and release of cysteine. Speed and amount of cysteine release can be controlled by release time, while -0.7 V and 12 mins are potential and time of release chosen in the experiment. The polymerized film is capable of loading and releasing drug in circle, with invariant pH response characteristic before and after release. It may serve a guidance for diagnosing and preventing some symptoms or diseases.

参考文献/References:

[1] 吴礼光, 刘茉娥, 朱长乐. 控制释放技术 [J]. 应用化学, 1994(3):1-10.
[2] 罗毅. 药物控制释放方法 [J]. 高分子通报, 1996(1):18-27.
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[4] 张文斌, 李一峻, 董绍俊. 电化学控制药物释放 [J]. 分析化学, 1991(7):843-848.
[5] 孙向英, 刘斌, 徐金瑞. 聚苯胺掺杂氨基化合物修饰电极的制作及其pH特性研究 [J]. 分析化学, 1996(1):120-121.
[6] 刘斌, 孙向英, 徐金瑞. Ni-Ti合金电极阴极溶出伏安法测定半胱氨酸的研究 [J]. 华侨大学学报(自然科学版), 1997(1):27-30.

更新日期/Last Update: 2014-03-23